Evidence map›Paper›PMID 32832407›Full record

ArticleAfrican journal of laboratory medicine2020

Prevalence of cryptococcal antigen (CrAg) among HIV-positive patients in Eswatini, 2014-2015.

Samson M Haumba, Mitsuru Toda, Rossana Jeffries, Peter Ehrenkranz, Munyaradzi Pasipamire, Trong Ao, Nomthandazo Lukhele, Sikhathele Mazibuko, Mandzisi Mkhontfo, Rachel M Smith and 1 more

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In one paragraph

Article in African journal of laboratory medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. African laboratory medicine in the time of COVID-19.African journal of laboratory medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Samson M HaumbaUniversity Research Co., LLC, Mbabane, Eswatini.ORCID https://orcid.org/0000-0001-5194-1247
Mitsuru TodaEpidemic Intelligence Service (EIS), Division of Scientific Education and Professional Development, Center for Surveillance, Epidemiology, and Laboratory Services (CSELS), Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, United States.ORCID https://orcid.org/0000-0002-5904-6658
Rossana JeffriesUniversity Research Co., LLC, Mbabane, Eswatini.ORCID https://orcid.org/0000-0003-2367-2072
Peter EhrenkranzGlobal Development, Bill and Melinda Gates Foundation, Seattle, Washington, United States.ORCID https://orcid.org/0000-0003-2028-4779
Munyaradzi PasipamireMinistry of Health Eswatini National AIDS Programme (ENAP), Mbabane, Eswatini.ORCID https://orcid.org/0000-0002-7409-6995
Trong AoCenters for Disease Control and Prevention (CDC), Mbabane, Eswatini.ORCID https://orcid.org/0000-0002-0775-5188
Nomthandazo LukheleMinistry of Health Eswatini National AIDS Programme (ENAP), Mbabane, Eswatini.ORCID https://orcid.org/0000-0001-6762-4334
Sikhathele MazibukoMinistry of Health Eswatini National AIDS Programme (ENAP), Mbabane, Eswatini.ORCID https://orcid.org/0000-0003-2811-2621
Mandzisi MkhontfoUniversity Research Co., LLC, Mbabane, Eswatini.ORCID https://orcid.org/0000-0002-3139-0027
Rachel M SmithMycotic Diseases Branch (MDB), Division of Foodborne, Waterborne, and Environmental Disease (DFWED), National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, United States.ORCID https://orcid.org/0000-0002-8337-1557
Tom ChillerMycotic Diseases Branch (MDB), Division of Foodborne, Waterborne, and Environmental Disease (DFWED), National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, United States.ORCID https://orcid.org/0000-0002-2251-8033
Centers for Disease Control and Prevention · USMinistry of Health · SZCenters for Disease Control and Prevention · UGGates Foundation · US

Funding

NCHHSTP CDC HHS U2G PS001896
6 · The paper itself

Abstract

backgroundCryptococcal meningitis is a leading cause of death amongst people living with HIV. However, routine cryptococcal antigen (CrAg) screening was not in the national guidelines in Eswatini.

objectivesA cross-sectional study was conducted between August 2014 and March 2015 to examine CrAg prevalence at Mbabane Government Hospital in Eswatini.

methodsWe collected urine and whole blood from antiretroviral-therapy-naïve patients with HIV and a cluster of differentiation 4 (CD4) counts < 200 cells/mm

resultsPlasma CrAg prevalence was 4% (8/182, 95% confidence interval [CI]: 2-8) amongst patients with CD4 counts of < 200 cells/mm

conclusionThe prevalence of CrAg in Eswatini was higher than the current global estimate of 6% amongst HIV-positive people with CD4 < 100 cell/mm

Indexed as

advanced HIV disease packagecryptococcal antigenaemia screeningcryptococcal meningitisEswatinipeople living with HIVprevalence

Identifiers

PMID32832407
PMCPMC7433303
OpenAlexW3047214024

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.