ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020
Oxytocin Differentially Modulates Amygdala Responses during Top-Down and Bottom-Up Aversive Anticipation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top-Down Middle Cingulate Amygdala Regulation and Brain-Wide Fear Representations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Trial
- The Angiotensin Antagonist Losartan Modulates Social Reward Motivation and Punishment Sensitivity via Modulating Midbrain-Striato-Frontal Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Trial
- Oxytocinergic Modulation of Stress-Associated Amygdala-Hippocampus Pathways in Humans Is Mediated by Serotonergic Mechanisms.The international journal of neuropsychopharmacology · 2022Trial
- A nuclei-specific fronto-amygdala pathway and its neurotransmitter receptor distribution: Implications for Antidepressant Selection.Molecular psychiatry · 2026Article
- The Amygdala and Politics.Brain sciences · 2026Review
- Interactive impacts of social deprivation and intranasal oxytocin administration on oxytocin receptor density in prairie vole brains.Frontiers in behavioral neuroscience · 2026Article
- Interoceptive NeuroEmpowerment Scale: a trauma-informed measure of adaptive state ownership.Frontiers in human neuroscience · 2026Article
- Increased salivary oxytocin correlates with lower self-reported interoceptive accuracy in functional neurological disorders.Neurobiology of stress · 2025Article
- Stereo-Electroencephalography Reveals Dynamic Spatio-Spectral Signatures of Negative Emotions: A Distributed Circuit Mechanism Involving Amygdala-Cingulate-Hippocampus-Orbitofrontal Networks.Brain and behavior · 2025Article
- Oxytocin and vasopressin enhance social pain empathy via common and distinct of neural expressions, genetic pathways, and networks.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A visual generalization gradient of conceptual stimuli based on fear acquisition in visual and auditory modalities.NPJ science of learning · 2025Article
- Enhanced disgust generalization in obsessive-compulsive disorder is related to insula and putamen hyperactivity.Psychological medicine · 2025Article
- Salivary oxytocin and amygdalar alterations in functional neurological disorders.Brain communications · 2025Article
- Psychophysiology of facial emotion recognition in psychopathy dimensions and oxytocin's role: A scoping review.PloS one · 2025Article
- Prenatal maternal life adversity impacts on learning and memory in offspring: implication to transgenerational epigenetic inheritance.Frontiers in neuroscience · 2025Article
- Oxytocin Enhances Time-Dependent Responses in the Aggressive Zebrafish (Brain sciences · 2024Article
- A neural signature for the subjective experience of threat anticipation under uncertainty.Nature communications · 2024Article
- Subcortical contributions to the sense of body ownership.Brain : a journal of neurology · 2024Article
- The neurocognitive impact of loneliness and social networks on social adaptation.Scientific reports · 2023Article
- Oxytocin enhances basolateral amygdala activation and functional connectivity while processing emotional faces: preliminary findings in autistic vs non-autistic women.Social cognitive and affective neuroscience · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to successfully regulate negative emotions such as fear and anxiety is vital for mental health. Intranasal administration of the neuropeptide oxytocin (OXT) has been shown to reduce amygdala activity but to increase amygdala-prefrontal cortex connectivity during exposure to threatening stimuli suggesting that it may act as an important modulator of emotion regulation. The present randomized, between-subject, placebo-controlled pharmacological study combines the intranasal administration of OXT with functional magnetic resonance imaging (fMRI) during an explicit emotion regulation paradigm in 65 healthy male participants to investigate the modulatory effects of OXT on both bottom-up and top-down emotion regulation. OXT attenuates the activation in the posterior insular cortex and amygdala during anticipation of top-down regulation of predictable threat stimuli in participants with high trait anxiety. In contrast, OXT enhances amygdala activity during the bottom-up anticipation of unpredictable threat stimuli in participants with low trait anxiety. OXT may facilitate top-down goal-directed attention by attenuating amygdala activity in high anxiety individuals, while promoting bottom-up attention/vigilance to unexpected threats by enhancing amygdala activity in low anxiety individuals. OXT may thus have the potential to promote an adaptive balance between bottom-up and top-down attention systems depending on an individual's trait anxiety level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.