Evidence map›Paper›PMID 32832310›Full record

ReviewAlcohol research : current reviews2020

The Role of Stress, Trauma, and Negative Affect in Alcohol Misuse and Alcohol Use Disorder in Women.

Maria Isabel Barros Guinle, Rajita Sinha

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alcohol research : current reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 4 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 4 syntheses or guidelines pooled it, 150 citations in OpenAlex.

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  14. Article
  15. BLA kappa opioid receptor inputs to the BNST mediate social stress-induced increases in alcohol drinking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  16. Sex-specific neural activation to stress and alcohol cues in high-risk drinkers: links between orbitofrontal circuits, alcohol craving, and future drinking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  17. Article
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  20. Rural-Urban Differences in Excessive Alcohol Use and Select Mental Health Conditions.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2026
    Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria Isabel Barros GuinleYale Stress Center, Yale School of Medicine, New Haven, Connecticut.
Rajita SinhaYale Stress Center, Yale School of Medicine, New Haven, Connecticut.
Yale Cancer Center · US

Funding

Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 1993 to 2026
$44.0M
Chronic Alcohol and Brain Stress Circuit ResponseR01AA013892 · NIAAA · YALE UNIVERSITY · PI Rajita Sinha · 2003 to 2026
$10.1M
Neuroactive Steroid Potentiation to Decrease Alcohol Craving, Normalize HPA axis function and Prevent Alcohol RelapseR01AA026514 · NIAAA · YALE UNIVERSITY · PI SINHA, RAJITA · 2018 to 2021
$2.8M
NIAAA NIH HHS R01 AA013892NIAAA NIH HHS R01 AA026514NIDDK NIH HHS P30 DK045735
6 · The paper itself

Abstract

Recent evidence indicates that the United States is facing a public health crisis of alcohol misuse and alcohol use disorder (AUD), which has been fueled in part by dramatic rises in binge and heavy drinking and prevalence of AUD in women. Historically, alcohol misuse and AUD have been more prevalent in men than in women. However, recent evidence on data from the past decade shows increases in AUD prevalence rates that are associated with substantially higher binge and heavy drinking and AUD prevalence in women compared to men. This paper first addresses the key roles of stress, trauma, childhood maltreatment, negative affect, and mood and anxiety disorders; sex differences in the presentation of these psychosocial and psychological factors; and their contributions to alcohol misuse, escalation to binge and heavy drinking, and transition to AUD in women. Also examined are potential central and peripheral biological mechanisms by which stressors and traumatic experiences, as well as chronic stress states-including depression and anxiety-may facilitate differential pathways to alcohol misuse, escalation, and transition to AUD in women. Finally, this paper discusses major gaps in the literature on sex differences in these areas as well as the need for greater research on sex-specific pathways to alcohol misuse and transition to AUD, so as to support a more comprehensive understanding of AUD etiology and for the development of new strategies for prevention and treatment of alcohol misuse and AUD in women.

Indexed as

AffectAdultAlcohol DrinkingAlcoholismChildEthanolFemaleHumansPrevalencePsychological TraumaSex CharacteristicsStress, PsychologicalUnited StatesEthanolalcohol cravingchild maltreatmentearly traumagirls and womensex differences

Identifiers

PMID32832310
PMCPMC7431322
OpenAlexW3008728387

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.