Evidence map›Paper›PMID 32832242›Full record

ArticleTranslational vision science & technology2020

Intraobserver Repeatability and Interobserver Reproducibility of Foveal Cone Density Measurements in

Michalis Georgiou, Katie M Litts, Navjit Singh, Thomas Kane, Emily J Patterson, Nashila Hirji, Angelos Kalitzeos, Alfredo Dubra, Michel Michaelides, Joseph Carroll

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Structural evaluation in inherited retinal diseases.The British journal of ophthalmology · 2021
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Michalis GeorgiouUCL Institute of Ophthalmology, University College London, London, UK.
Katie M LittsDepartment of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
Navjit SinghUCL Institute of Ophthalmology, University College London, London, UK.
Thomas KaneUCL Institute of Ophthalmology, University College London, London, UK.
Emily J PattersonUCL Institute of Ophthalmology, University College London, London, UK.
Nashila HirjiUCL Institute of Ophthalmology, University College London, London, UK.
Angelos KalitzeosUCL Institute of Ophthalmology, University College London, London, UK.
Alfredo DubraDepartment of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Michel MichaelidesUCL Institute of Ophthalmology, University College London, London, UK.
Joseph CarrollDepartment of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
Moorfields Eye Hospital · GBMedical College of Wisconsin · USUniversity College London · GBMoorfields Eye Hospital NHS Foundation Trust · GBStanford University · US

Funding

Assessing Photoreceptor Structure and Function in Normal and Diseased RetinaeR01EY017607 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Joseph Carroll · 2008 to 2026
$8.3M
Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Platform Technologies for Microscopic Retinal Imaging: Development & TranslationU01EY025477 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2015 to 2019
$4.4M
Axially-resolved Spectroscopic Ophthalmic ImagingR01EY025231 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2015 to 2019
$1.9M
Multimodal Imaging of Photoreceptor Structure in AchromatopsiaF32EY029148 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI LITTS, KATIE M · 2018 to 2020
$148k
NEI NIH HHS F32 EY029148NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY017607NEI NIH HHS R01 EY025231NEI NIH HHS U01 EY025477Wellcome TrustWellcome Trust 099173/Z/12/Z
6 · The paper itself

Abstract

Purpose: To examine repeatability and reproducibility of foveal cone density measurements in patients with Methods: Thirty foveae from molecularly confirmed subjects with ACHM, half of whom harbored disease-causing variants in Results: We observed excellent intraobserver repeatability in foveal cone density estimates, with intraclass correlation coefficients (ICCs) ranging from 0.963 to 0.991 for Conclusions: Foveal cone density can be measured using the described method with good repeatability and reproducibility both for Translational Relevance: This approach could be used to explore disease natural history, as well as to facilitate stratification of patients and monitor efficacy of interventions for ongoing and upcoming ACHM gene therapy trials.

Indexed as

Color Vision DefectsCyclic Nucleotide-Gated Cation ChannelsFovea CentralisHumansReproducibility of ResultsRetinal Cone Photoreceptor CellsCNGA3 protein, humanCNGB3 protein, humanCyclic Nucleotide-Gated Cation Channelsachromatopsiaadaptive opticscone photoreceptorsinherited retinal diseasesrepeatabilityreproducibility

Identifiers

PMID32832242
PMCPMC7414701
OpenAlexW3037411560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.