ArticleTranslational vision science & technology2020
Cognitive Impairment and Lamina Cribrosa Thickness in Primary Open-Angle Glaucoma.
Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Hippocampal subregions functional connectivity alterations in primary angle-closure glaucoma patients with cognitive dysfunction: a resting-state fMRI study.BMC neurology · 2025Article
- Association Analysis between Cognitive Function Score and Inner Macular Thickness/Visual Field Sensitivity in Glaucoma Patients.Journal of clinical medicine · 2024Article
- Targeting the Cerebrospinal Fluid Compartment in Glaucoma: Still the Dark Side of the Moon? Comment on Passaro et al. Glaucoma as a Tauopathy-Is It the Missing Piece in the Glaucoma Puzzle?Journal of clinical medicine · 2024Article
- Roles of Cognitive Function on Visual Field Reliability Indices among Glaucoma Patients.Journal of clinical medicine · 2023Article
- Glaucoma as a Tauopathy-Is It the Missing Piece in the Glaucoma Puzzle?Journal of clinical medicine · 2023Review
- Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future.Frontiers in neurology · 2022Review
- Implicating Causal Brain Magnetic Resonance Imaging in Glaucoma Using Mendelian Randomization.Frontiers in medicine · 2022Article
- Cognitive Dysfunctions in Glaucoma: An Overview of Morpho-Functional Mechanisms and the Impact on Higher-Order Visual Function.Frontiers in aging neuroscience · 2021Review
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The purpose of this study was to investigate the relationship between the lamina cribrosa (LC) thickness (LCT) as assessed using enhanced depth-imaging (EDI) optical coherence tomography (OCT) and cognitive function in primary open-angle glaucoma (POAG). Methods: The study consisted of 105 POAG eyes and 23 nonglaucomatous control eyes that completed neuropsychological tests. The optic nerve heads of the patients were imaged using EDI-OCT. B-scan images were constructed in three dimensions using maximum intensity projection (MIP), and the LCT was measured using the thin-slab MIP images. A comprehensive battery consisting of 15 neuropsychological tests was used to evaluate cognitive function. Results: POAG eyes had smaller mean LCT as compared with control eyes ( Conclusions: Impairment of cognitive function was observed in patients with POAG with a thinner LC. The role of LC imaging as a potential biomarker to monitor cognitive impairment needs further investigation. Translational Relevance: LC thinning may reflect a shared mechanism of neurodegenerative diseases in the brain and optic nerve.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.