ArticleTranslational vision science & technology2020
Depth-Dependent Corneal Biomechanical Properties in Normal and Keratoconic Subjects by Optical Coherence Elastography.
Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 69 citations in OpenAlex.
- Integration of Mechanical Testing, In Vivo Optical Coherence Elastography and Personalized Finite Element Modeling to Predict Geometrical Outcomes of Corneal Cross-Linking.Annals of biomedical engineering · 2026Article
- Motion-Tracking Brillouin Microscopy for Keratoconus Suspect Identification: Comparison With Multimodal Corneal Imaging.American journal of ophthalmology · 2026Article
- In Vivo Biomechanical Characteristics of Human Corneas With Phase-Decorrelation OCT.Investigative ophthalmology & visual science · 2026Article
- Roadmap on advances in visual and physiological optics.Journal of optics (2010) · 2025Review
- Three-Dimensional Mechanical Characterization of Normal, Subclinical, and Keratoconic Corneas Using Motion Tracking Brillouin Microscopy.American journal of ophthalmology · 2025Article
- Evaluating corneal cross-linking using Stress-Strain Index maps: a finite element study.Journal of the Royal Society, Interface · 2025Article
- Riboflavin-UV crosslinking of the cornea: Wound healing and biomechanics.Experimental eye research · 2025Review
- Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography.Translational vision science & technology · 2025Article
- Corneal Biomechanical Changes Induced by Chronic Elevated Intraocular Pressure: Implications for Glaucoma Pathogenesis and Management.Journal of ophthalmology · 2025Review
- The Contribution of the Limbus and Collagen Fibrils to Corneal Biomechanical Properties: Estimation of the Low-Strain In Vivo Elastic Modulus and Tissue Strain.Biomimetics (Basel, Switzerland) · 2024Article
- Dynamic evaluation of corneal cross-linking and osmotic diffusion effects using optical coherence elastography.Scientific reports · 2024Article
- Keratectasia severity staging and progression assessment based on the biomechanical E-staging.Eye and vision (London, England) · 2024Review
- Multi-modal imaging for the detection of early keratoconus: a narrative review.Eye and vision (London, England) · 2024Review
- Dual-channel air-pulse optical coherence elastography for frequency-response analysis.Biomedical optics express · 2024Article
- Longitudinal Analysis of Corneal Biomechanics of Suspect Keratoconus: A Prospective Case-Control Study.Bioengineering (Basel, Switzerland) · 2024Article
- Subclinical Keratoconus Detection and Characterization Using Motion-Tracking Brillouin Microscopy.Ophthalmology · 2024Article
- In Vivo Evaluation of Corneal Biomechanics Following Cross-Linking Surgeries Using Optical Coherence Elastography in a Rabbit Model of Keratoconus.Translational vision science & technology · 2024Article
- Motion-Tracking Brillouin Microscopy Evaluation of Normal, Keratoconic, and Post-Laser Vision Correction Corneas.American journal of ophthalmology · 2023Article
- Acoustic Micro-Tapping Optical Coherence Elastography to Quantify Corneal Collagen Cross-Linking: An Ex Vivo Human Study.Ophthalmology science · 2023Article
- Biomechanical properties analysis of forme fruste keratoconus and subclinical keratoconus.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Purpose: Compare depth-resolved biomechanical properties in normal and keratoconic corneas in live human subjects using optical coherence elastography (OCE). Methods: In a prospective series of normal and keratoconus (KC) eyes, a corneal perturbation was applied by a custom swept-source OCE system using a transparent flat lens coupled to force transducers. Cross-correlation was applied to track frame-by-frame OCT speckle displacement. Regional displacements for the anterior and posterior stroma were plotted in force versus displacement ( Results: Thirty-six eyes were analyzed (21 eyes of 12 normal subjects and 15 KC eyes of 12 subjects). The Conclusions: Significant differences in depth-dependent corneal biomechanical properties were observed between normal and KC subjects. Translational Relevance: OCE was applied for the first time to human KC subjects and revealed alterations in the normal anterior-to-posterior stromal stiffness gradient, a novel and clinically accessible disease biomarker.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.