Evidence map›Paper›PMID 32832051›Full record

ArticleChemical science2020

Visualizing semipermeability of the cell membrane using a pH-responsive ratiometric AIEgen.

Yuan Gu, Zheng Zhao, Guangle Niu, Han Zhang, Yiming Wang, Ryan T K Kwok, Jacky W Y Lam, Ben Zhong Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. The Bioimaging Story of AIEgens.Chemical & biomedical imaging · 2023
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuan GuDepartment of Chemical and Biological Engineering , Department of Chemistry , The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong 999077 , China . Email: tangbenz@ust.hk.
Zheng ZhaoDepartment of Chemical and Biological Engineering , Department of Chemistry , The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong 999077 , China . Email: tangbenz@ust.hk.ORCID 0000-0002-5536-0439
Guangle NiuDepartment of Chemical and Biological Engineering , Department of Chemistry , The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong 999077 , China . Email: tangbenz@ust.hk.
Han ZhangCenter for Aggregation-Induced Emission , SCUT-HKUST Joint Research Institute , State Key Laboratory of Luminescent Materials and Devices , South China University of Technology , Guangzhou 510640 , China.ORCID 0000-0003-4069-1769
Yiming WangDepartment of Chemical and Biological Engineering , Department of Chemistry , The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong 999077 , China . Email: tangbenz@ust.hk.
Ryan T K KwokDepartment of Chemical and Biological Engineering , Department of Chemistry , The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong 999077 , China . Email: tangbenz@ust.hk.
Jacky W Y LamDepartment of Chemical and Biological Engineering , Department of Chemistry , The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong 999077 , China . Email: tangbenz@ust.hk.
Ben Zhong TangDepartment of Chemical and Biological Engineering , Department of Chemistry , The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong 999077 , China . Email: tangbenz@ust.hk.ORCID 0000-0002-0293-964X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In clinical chemotherapy, some basic drugs cannot enter the hydrophobic cell membrane because of ionization in the acidic tumor microenvironment, a phenomenon known as ion trapping. In this study, we developed a method to visualize this ion trapping phenomenon by utilizing a pH-responsive ratiometric AIEgen, dihydro berberine (

Identifiers

PMID32832051
PMCPMC7422962

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.