ArticleACS medicinal chemistry letters2020
Automation of Synthesis in Medicinal Chemistry: Progress and Challenges.
Article in ACS medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- SynthesizabilityChemical science · 2026Article
- Accelerating compound synthesis in drug discovery: the role of digitalisation and automation.RSC medicinal chemistry · 2025Article
- Intelligent Systems for Inorganic Nanomaterial Synthesis.Nanomaterials (Basel, Switzerland) · 2025Review
- Five-membered heterocycles as promising platforms for molecular logic gate construction.RSC advances · 2025Review
- An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization.Angewandte Chemie (International ed. in English) · 2024Article
- An Automated Purification Workflow Coupled with Material-Sparing High-ThroughputACS medicinal chemistry letters · 2024Article
- Calibration-free reaction yield quantification by HPLC with a machine-learning model of extinction coefficients.Chemical science · 2024Article
- Continuous flow synthesis enabling reaction discovery.Chemical science · 2024Review
- Establishing and testing a robot-based platform to enable the automated production of nanoparticles in a flexible and modular way.Scientific reports · 2023Article
- Automation isn't automatic.Chemical science · 2021Review
- Artificial Intelligence for Autonomous Molecular Design: A Perspective.Molecules (Basel, Switzerland) · 2021Review
- Inferring experimental procedures from text-based representations of chemical reactions.Nature communications · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the 1990s, concerted attempts have been made to improve the efficiency of medicinal chemistry synthesis tasks using automation. Although impacts have been seen in some tasks, such as small array synthesis and reaction optimization, many synthesis tasks in medicinal chemistry are still manual. As it has been shown that synthesis technology has a large effect on the properties of the compounds being tested, this review looks at recent research in automation relevant to synthesis in medicinal chemistry. A common theme has been the integration of tasks, as well as the use of increased computing power to access complex automation platforms remotely and to improve synthesis planning software. However, there has been more limited progress in modular tools for the medicinal chemist with a focus on autonomy rather than automation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.