Evidence map›Paper›PMID 32831973›Full record

ArticleDisease markers2020

Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia.

Juan Li, Shoulin Li, Yihong Song, Wei Zhou, Xiaohao Zhu, Suo Xu, Yihong Ma, Chunlin Zhu

Open access · hybridAbstract read
In one paragraph

Article in Disease markers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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  5. Can Adipokine FAM19A5 Be a Biomarker of Metabolic Disorders?Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Juan LiDepartment of Neurology, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.
Shoulin LiDepartment of Emergency Medicine, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.
Yihong SongDepartment of Neurology, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.
Wei ZhouDepartment of Emergency Medicine, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.
Xiaohao ZhuDepartment of Emergency Medicine, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.
Suo XuDepartment of Emergency Medicine, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.
Yihong MaDepartment of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Chunlin ZhuDepartment of Neurology, The First People's Hospital of Lianyungang/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China.ORCID https://orcid.org/0000-0001-5495-3227
The First People’s Hospital of Lianyungang · CNKumamoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFamily with sequence similarity 19 member A5 (FAM19A5), a novel chemokine-like peptide, is a secreted protein mainly expressed in the brain. FAM19A5 was recently found to be involved in a variety of neurological diseases; however, its correlation with vascular dementia (VaD) remains unclear. The aim of the study is to explore the association between serum FAM19A5 and cognitive impairment in subjects with VaD.

method136 VaD subjects and 81 normal controls were recruited in the study. Their demographic and clinical baseline data were collected on admission. All subjects received Mini-Mental State Examination (MMSE) evaluation, which was used to test their cognitive functions. A sandwich enzyme-linked immunosorbent assay (ELISA) was applied to detect the serum levels of FAM19A5.

resultsNo significant differences were found between the two groups regarding the demographic and clinical baseline data (

conclusionThe serum FAM19A5 level of VaD patients is significantly increased, which may serve as a biomarker to predict cognitive function of VaD.

Indexed as

Up-RegulationAgedBiomarkersCase-Control StudiesCognitive DysfunctionCytokinesDementia, VascularFemaleHumansMaleMental Status and Dementia TestsMiddle AgedRegression AnalysisBiomarkersCytokinesTAFA5 protein, human

Identifiers

PMID32831973
PMCPMC7422492
OpenAlexW3047341465

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.