Evidence map›Paper›PMID 32831971›Full record

ArticleDisease markers2020

Investigating the GWAS-Implicated Loci for Rheumatoid Arthritis in the Pakistani Population.

Muhammad Muaaz Aslam, Peter John, Kang-Hsien Fan, Attya Bhatti, Wajahat Aziz, Bashir Ahmed, Eleanor Feingold, F Yesim Demirci, M Ilyas Kamboh

Open access · hybridAbstract read
In one paragraph

Article in Disease markers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  4. Genes · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Muhammad Muaaz AslamAtta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan.ORCID https://orcid.org/0000-0003-1817-7894
Peter JohnAtta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan.
Kang-Hsien FanDepartment of Human Genetics, Graduate School of Public Health (GSPH), University of Pittsburgh, Pittsburgh, PA, USA.
Attya BhattiAtta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan.
Wajahat AzizDepartment of Rheumatology, Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan.
Bashir AhmedDepartment of Rheumatology, Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan.
Eleanor FeingoldDepartment of Human Genetics, Graduate School of Public Health (GSPH), University of Pittsburgh, Pittsburgh, PA, USA.
F Yesim DemirciDepartment of Human Genetics, Graduate School of Public Health (GSPH), University of Pittsburgh, Pittsburgh, PA, USA.
M Ilyas KambohDepartment of Human Genetics, Graduate School of Public Health (GSPH), University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-3453-1438
University of Pittsburgh · USNational University of Sciences and Technology · PKPakistan Institute of Medical Sciences · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a complex and multifactorial autoimmune disorder with the involvement of multiple genetic and environmental factors. Genome-wide association studies (GWAS) have identified more than 50 RA genetic loci in European populations. Given the anticipated overlap of RA-relevant genes and pathways across different ethnic groups, we sought to replicate 58 GWAS-implicated SNPs reported in Europeans in Pakistani subjects. 1,959 unrelated subjects comprising 1,222 RA cases and 737 controls were collected from three rheumatology facilities in Pakistan. Genotyping was performed using iPLEX or TaqMan® methods. A total of 50 SNPs were included in the final association analysis after excluding those that failed assay design/run or postrun QC analysis. Fourteen SNPs (

Indexed as

Gene Regulatory NetworksPolymorphism, Single NucleotideAdultArthritis, RheumatoidCase-Control StudiesEuropeFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedPakistan

Identifiers

PMID32831971
PMCPMC7422001
OpenAlexW3046980291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.