Serum Peptidomic Profile as a Novel Biomarker for Rheumatoid Arthritis.

Abeer A Abdelati, Rehab A Elnemr, Noha S Kandil, Fatma I Dwedar, Rasha A Ghazala

Abstract read

In one paragraph

Article in International journal of rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Abeer A AbdelatiDepartment of Internal Medicine, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Alexandria University, Alexandria 21612, Egypt.ORCID https://orcid.org/0000-0002-1460-0619

Rehab A ElnemrDepartment of Physical Medicine Rheumatology and Rehabilitation, Faculty of Medicine, Alexandria University, Alexandria 22511, Egypt.ORCID https://orcid.org/0000-0001-9604-4937

Noha S KandilDepartment of Chemical Pathology, Medical Research Institute, Alexandria University, Alexandria 21523, Egypt.

Fatma I DwedarDepartment of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria 21648, Egypt.

Rasha A GhazalaDepartment of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria 21648, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the last decades, there has been an increasing need to discover new diagnostic RA biomarkers, other than the current serologic biomarkers, which can assist early diagnosis and response to treatment. The purpose of this study was to analyze the serum peptidomic profile in patients with rheumatoid arthritis (RA) by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). The study included 35 patients with rheumatoid arthritis (RA), 35 patients with primary osteoarthritis (OA) as the disease control (DC), and 35 healthy controls (HC). All participants were subjected to serum peptidomic profile analysis using magnetic bead (MB) separation (MALDI-TOF-MS). The trial showed 113 peaks that discriminated RA from OA and 101 peaks that discriminated RA from HC. Moreover, 95 peaks were identified and discriminated OA from HC; 38 were significant (

Identifiers

PMID32831850

DOI10.1155/2020/6069484

PMCPMC7422355

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.