ArticleMediators of inflammation2020
Clinical Features at Onset and Genetic Characterization of Pediatric and Adult Patients with TNF-
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05200715 (Development of an International Multicenter Registry of Patients With Monogenic and Polygenic Autoinflammatory Diseases Aimed at Clinical and Therapeutical Data Collection and Analysis), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of an International Multicenter Registry of Patients With Monogenic and Polygenic Autoinflammatory Diseases Aimed at Clinical and Therapeutical Data Collection and Analysis
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Immunomodulating Therapies in Acute Myocarditis and Recurrent/Acute Pericarditis.Frontiers in medicine · 2022Pooled it
- Clinical and laboratory manifestations and treatment of children withWorld journal of clinical pediatrics · 2026Article
- Long-term Effectiveness and Safety of Canakinumab in Patients with TRAPS: Analysis of the RELIANCE Non-Interventional Study.Rheumatology and therapy · 2026Article
- Tumor Necrosis Factor Receptor-Associated Periodic Syndrome: Genetics, Autoinflammation, and Recurrent Pericarditis.JACC. Case reports · 2025Article
- Cardiovascular involvement in children with COVID-19 temporally related multisystem inflammatory syndrome (MIS-C): can cardiac magnetic resonance arrive to the heart of the problem?Italian journal of pediatrics · 2024Article
- Knowledge and Current Practices in Monogenic Uveitis: An International Survey by IUSG and AIDA Network.Ophthalmology and therapy · 2024Article
- A rare missense p.C125Y mutation in theFrontiers in genetics · 2024Article
- Article
- Dermatologic Manifestations of Noninflammasome-Mediated Autoinflammatory Diseases.JID innovations : skin science from molecules to population health · 2023Review
- Tumor necrosis factor receptor-associated cycle syndrome: a case report and literature review.Frontiers in pediatrics · 2023Article
- Autoinflammatory manifestations in adult patients.Clinical and experimental immunology · 2022Article
- IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting.Nature reviews. Rheumatology · 2022Review
- Systemic Autoinflammatory Diseases: A Growing Family of Disorders of Overlapping Immune Dysfunction.Rheumatic diseases clinics of North America · 2022Review
- [What is confirmed in the treatment of autoinflammatory fever diseases?]Der Internist · 2021Review
- Autoimmune and Autoinflammatory Pericarditis: Definitions and New Treatments.Current cardiology reports · 2021Review
- Monogenic Adult-Onset Inborn Errors of Immunity.Frontiers in immunology · 2021Review
- Real-Life Indications of Interleukin-1 Blocking Agents in Hereditary Recurrent Fevers: Data From the JIRcohort and a Literature Review.Frontiers in immunology · 2021Review
- Anakinra and canakinumab for patients with R92Q-associated autoinflammatory syndrome: a multicenter observational study from the AIDA Network.Therapeutic advances in musculoskeletal disease · 2021Article
- Biotechnological Agents for Patients With Tumor Necrosis Factor Receptor Associated Periodic Syndrome-Therapeutic Outcome and Predictors of Response: Real-Life Data From the AIDA Network.Frontiers in medicine · 2021Article
- Management of Monogenic IL-1 Mediated Autoinflammatory Diseases in Childhood.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors at 19 institutions in 2 countries.
Carla GaggianoClinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, Siena, Italy.ORCID https://orcid.org/0000-0003-1401-8343
Antonio VitaleResearch Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.ORCID https://orcid.org/0000-0003-4469-7332
Laura ObiciAmyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Giampaolo MerliniAmyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.ORCID https://orcid.org/0000-0001-7680-3254
Alessandra SorianoDepartment of Internal Medicine, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
Ombretta ViapianaRheumatology Section, Department of Medicine, University of Verona, Verona, Italy.
Marco CattaliniPaediatric Clinic, University of Brescia and Spedali Civili di Brescia, Brescia, Italy.
Maria Cristina MaggioUniversitary Department "Pro.S.A.M.I.", University of Palermo, Palermo, Italy.
Giuseppe LopalcoRheumatology Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.ORCID https://orcid.org/0000-0003-4524-9566
Davide MontinDivision of Immunology and Rheumatology, Department of Paediatric Infectious Diseases, University of Turin, Regina Margherita Children's Hospital, Turin, Italy.
Masen Abdel JaberRheumatology Unit, Santa Chiara Hospital, Trento, Italy.
Lorenzo DagnaUnit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Raffaele MannaPeriodic Fever Research Center, Institute of Internal Medicine, Catholic University of the Sacred Heart, Fondazione Policlinico A. Gemelli, Rome, Italy.ORCID https://orcid.org/0000-0003-1560-3907
Antonella InsalacoDivision of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Matteo PigaRheumatology Unit, Department of Medical Sciences, University and AOU of Cagliari, Cagliari, Italy.ORCID https://orcid.org/0000-0002-1126-8315
Francesco La TorreClinical Pediatrics, University of Bari, Bari, Italy.
Virginia BerlengieroResearch Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Viviana GelardiResearch Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Luisa CiarciaResearch Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Giacomo EmmiDepartment of Experimental and Clinical Medicine, University of Firenze, Florence, Italy.ORCID https://orcid.org/0000-0001-9575-8321
Piero RuscittiRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.
Francesco CasoRheumatology Unit, Department of Clinical Medicine and Surgery, School of Medicine and Surgery, University Federico II, Naples, Italy.ORCID https://orcid.org/0000-0002-8928-2520
Rolando CimazDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
José Hernández-RodríguezVasculitis Research Unit and Autoinflammatory Diseases Clinical Unit, Department of Autoimmune Diseases, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.
Paola ParronchiDepartment of Experimental and Clinical Medicine, University of Firenze, Florence, Italy.
Ludovico Luca SicignanoPeriodic Fever Research Center, Institute of Internal Medicine, Catholic University of the Sacred Heart, Fondazione Policlinico A. Gemelli, Rome, Italy.
Elena VerrecchiaPeriodic Fever Research Center, Institute of Internal Medicine, Catholic University of the Sacred Heart, Fondazione Policlinico A. Gemelli, Rome, Italy.
Florenzo IannoneRheumatology Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.ORCID https://orcid.org/0000-0003-0474-5344
Jurgen SotaResearch Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.ORCID https://orcid.org/0000-0002-7549-2922
Salvatore GrossoClinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, Siena, Italy.
Carlo SalvaraniDepartment of Internal Medicine, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
Bruno FredianiResearch Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Roberto GiacomelliRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.
Maria Antonietta MencarelliGenetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Alessandra RenieriGenetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.ORCID https://orcid.org/0000-0002-0846-9220
Donato RiganteInstitute of Pediatrics, Periodic Fever Research Center, Università Cattolica Sacro Cuore, Fondazione Policlinico A. Gemelli, IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0001-7032-7779
Luca CantariniResearch Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.ORCID https://orcid.org/0000-0002-7352-1275
University of Siena · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Bari Aldo Moro · ITOspedale Santa Maria · ITPoliclinico San Matteo Fondazione · ITUniversity of Florence · ITUniversity of L'Aquila · ITAzienda Ospedaliera Universitaria Senese · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITBambino Gesù Children's Hospital · ITConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESFederico II University Hospital · ITOspedale Regina Margherita · ITOspedale Santa Chiara · ITUniversity of Cagliari · ITUniversity of Milan · ITUniversity of Palermo · ITUniversity of Verona · ITVita-Salute San Raffaele University · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study explores demographic, clinical, and therapeutic features of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a cohort of 80 patients recruited from 19 Italian referral Centers. Patients' data were collected retrospectively and then analyzed according to age groups (disease onset before or after 16 years) and genotype (high penetrance (HP) and low penetrance (LP)
Indexed as
AdolescentAdultAnimalsChildChild, PreschoolFamilial Mediterranean FeverFemaleGenotypeHumansInfantMaleMutationMyalgiaPericarditisPrognosisReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type ITNFRSF1A protein, humanTumor Necrosis Factor-alpha
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT05200715ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.