ArticleThe Journal of cell biology1988
Intracellular targeting of isoproteins in muscle cytoarchitecture.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 52 citations in OpenAlex.
- Creatine kinase B is necessary to limit myoblast fusion during myogenesis.American journal of physiology. Cell physiology · 2015Article
- Phosphocreatine as an energy source for actin cytoskeletal rearrangements during myoblast fusion.The Journal of physiology · 2008Article
- Isoenzyme-specific interaction of muscle-type creatine kinase with the sarcomeric M-line is mediated by NH(2)-terminal lysine charge-clamps.The Journal of cell biology · 2000Article
- Different domains of the M-band protein myomesin are involved in myosin binding and M-band targeting.Molecular biology of the cell · 1999Article
- Mobility of creatine phosphokinase and beta-enolase in cultured muscle cells.Biophysical journal · 1997Article
- Transfer of macromolecules into living adult cardiomyocytes by microinjection.Molecular and cellular biochemistry · 1997Article
- Dominant negative effect of cytoplasmic actin isoproteins on cardiomyocyte cytoarchitecture and function.The Journal of cell biology · 1995Article
- Equilibration and exchange of fluorescently labeled molecules in skinned skeletal muscle fibers visualized by confocal microscopy.Biophysical journal · 1995Article
- Differential localization of the mRNA of the M and B isoforms of creatine kinase in myoblasts.The Biochemical journal · 1995Article
- Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis.The Biochemical journal · 1992Review
- A brief summary of the history of the detection of creatine kinase isoenzymes.Molecular and cellular biochemistryArticle
- Myofibrillar creatine kinase and cardiac contraction.Molecular and cellular biochemistryReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Part of the muscle creatine kinase (MM-CK) in skeletal muscle of chicken is localized in the M-band of myofibrils, while chicken heart cells containing myofibrils and BB-CK, but not expressing MM-CK, do not show this association. The specificity of the MM-CK interaction was tested using cultured chicken heart cells as "living test tubes" by microinjection of in vitro generated MM-CK and hybrid M-CK/B-CK mRNA with SP6 RNA polymerase. The resulting translation products were detected in injected cells with isoprotein-specific antibodies. M-CK molecules and translation products of chimeric cDNA molecules containing the head half of the B-CK and the tail half of the M-CK coding regions were localized in the M-band of the myofibrils. The tail, but not the head portion of M-CK is essential for the association of M-CK with the M-band of myofibrils. We conclude that gross biochemical properties do not always coincide with a molecule's specific functions like the participation in cell cytoarchitecture which may depend on molecular targeting even within the same cellular compartment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.