Evidence map›Paper›PMID 32831434›Full record

ArticleTrends in analytical chemistry : TRAC2019

Opening new paths for biological applications of ion mobility - mass spectrometry using Structures for Lossless Ion Manipulations.

Sandilya V B Garimella, Gabe Nagy, Yehia M Ibrahim, Richard D Smith

Open access · greenAbstract read
In one paragraph

Article in Trends in analytical chemistry : TRAC, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

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  10. Enhancing the Depth of Analyses with Next-Generation Ion Mobility Experiments.Annual review of analytical chemistry (Palo Alto, Calif.) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sandilya V B GarimellaPacific Northwest National Laboratory, Richland, WA, USA.
Gabe NagyPacific Northwest National Laboratory, Richland, WA, USA.
Yehia M IbrahimPacific Northwest National Laboratory, Richland, WA, USA.
Richard D SmithPacific Northwest National Laboratory, Richland, WA, USA.
Pacific Northwest National Laboratory · US

Funding

Equipment Supplement Request for a Research Resource for Ultra-sensitive High Throughput ProteomicsP41GM103493 · NIGMS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI SMITH, RICHARD D · 2012 to 2022
$22.6M
The Cerebrospinal Fluid Proteome in HIV-1 Infection and Opiate AddictionP01DA026134 · NIDA · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI PRICE, RICHARD W. · 2008 to 2010
$3.0M
NIDA NIH HHS P01 DA026134NIGMS NIH HHS P41 GM103493
6 · The paper itself

Abstract

Ion mobility separations coupled to mass spectrometry (IM-MS) have received much attention for their ability to provide complementary structural information to solution-phase-based separations, as well as to aid in the identification of unknown compounds. While IM-MS is an increasingly powerful analytical technique, significant bottlenecks related to the resolution of measurements have kept it from becoming broadly applied for biological analyses. Presently, IM-MS-based measurements also remain limited in terms of their sensitivity as compared to state of the art MS-based approaches alone. Structures for Lossless Ion Manipulations (SLIM)-based IM separations provide a basis for overcoming these bottlenecks, addressing issues associated with resolution and sensitivity in the omics, and potentially opening the door to much broader application.

Identifiers

PMID32831434
PMCPMC7441749
OpenAlexW2943627831

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.