ArticleThe Journal of clinical investigation2020
Mapping mania symptoms based on focal brain damage.
Article in The Journal of clinical investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Understanding Deep Brain Stimulation-induced Mania: Finding Potential Predictors to Optimize Treatment
Improving Obsessive-compulsive Disorder Treatments: from Lesions to Neuromodulation Targets
Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- Efficacy, Effectiveness, and Safety of Transcranial Magnetic Stimulation for Bipolar Depression: A Systematic Review and Meta-Analysis.Biological psychiatry global open science · 2026Article
- Network localization of genetic risk for schizophrenia and bipolar disorder.Psychological medicine · 2025Article
- Dorsomedial and ventromedial prefrontal cortex lesions differentially impact social influence and temporal discounting.PLoS biology · 2025Article
- Managing a Complex Case of Bipolar Disorder in a Patient With Recurrent Hospitalizations.Cureus · 2024Article
- A neural circuit for spatial orientation derived from brain lesions.Cerebral cortex (New York, N.Y. : 1991) · 2024Review
- Advances in functional MRI research in bipolar disorder: from the perspective of mood states.General psychiatry · 2024Review
- Article
- Mapping Lesion-Related Epilepsy to a Human Brain Network.JAMA neurology · 2023Article
- Localization of a Medial Temporal Lobe-Precuneus Network for Time Orientation.Annals of neurology · 2023Article
- Large-scale lesion symptom mapping of depression identifies brain regions for risk and resilience.Brain : a journal of neurology · 2023Article
- Multimodal and multidomain lesion network mapping enhances prediction of sensorimotor behavior in stroke patients.Scientific reports · 2022Article
- Lesion network mapping of mania using different normative connectomes.Brain structure & function · 2022Article
- Network Effects of Brain Lesions Causing Central Poststroke Pain.Annals of neurology · 2022Article
- Strategies and foundations for scientific discovery in longitudinal studies of bipolar disorder.Bipolar disorders · 2022Review
- Causal mapping of human brain function.Nature reviews. Neuroscience · 2022Review
- Using causal methods to map symptoms to brain circuits in neurodevelopment disorders: moving from identifying correlates to developing treatments.Journal of neurodevelopmental disorders · 2022Review
- A Neural Circuit for Spirituality and Religiosity Derived From Patients With Brain Lesions.Biological psychiatry · 2022Article
- Network Localization of Unconscious Visual Perception in Blindsight.Annals of neurology · 2022Article
- Functional neuroanatomy of mania.Translational psychiatry · 2022Review
- Circuit-Targeted Neuromodulation for Anhedonia.Current topics in behavioral neurosciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 4 countries.
Funding
Abstract
BACKGROUNDAlthough mania is characteristic of bipolar disorder, it can also occur following focal brain damage. Such cases may provide unique insight into brain regions responsible for mania symptoms and identify therapeutic targets.METHODSLesion locations associated with mania were identified using a systematic literature search (n = 41) and mapped onto a common brain atlas. The network of brain regions functionally connected to each lesion location was computed using normative human connectome data (resting-state functional MRI, n = 1000) and contrasted with those obtained from lesion locations not associated with mania (n = 79). Reproducibility was assessed using independent cohorts of mania lesions derived from clinical chart review (n = 15) and of control lesions (n = 490). Results were compared with brain stimulation sites previously reported to induce or relieve mania symptoms.RESULTSLesion locations associated with mania were heterogeneous and no single brain region was lesioned in all, or even most, cases. However, these lesion locations showed a unique pattern of functional connectivity to the right orbitofrontal cortex, right inferior temporal gyrus, and right frontal pole. This connectivity profile was reproducible across independent lesion cohorts and aligned with the effects of therapeutic brain stimulation on mania symptoms.CONCLUSIONBrain lesions associated with mania are characterized by a specific pattern of brain connectivity that lends insight into localization of mania symptoms and potential therapeutic targets.FUNDINGFundação para a Ciência e Tecnologia (FCT), Harvard Medical School DuPont-Warren Fellowship, Portuguese national funds from FCT and Fundo Europeu de Desenvolvimento Regional, Child Neurology Foundation Shields Research, Sidney R. Baer, Jr. Foundation, Nancy Lurie Marks Foundation, Mather's Foundation, and the NIH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.