ArticleeLife2020
The contribution of asymptomatic SARS-CoV-2 infections to transmission on the Diamond Princess cruise ship.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05290792 (Use of Wearable Sensors for Early Detection and Tracking of Viral Respiratory Tract Infections), which is not on this map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Wearable Sensors for Early Detection and Tracking of Viral Respiratory Tract Infections: The WE SENSE Study
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Meta-analysis of COVID-19 prevalence during preoperative COVID-19 screening in asymptomatic patients.BMJ open · 2022Pooled it
- Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis.PLoS medicine · 2022Pooled it
- Systematic Review on Outbreaks of SARS-CoV-2 on Cruise, Navy and Cargo Ships.International journal of environmental research and public health · 2021Pooled it
- C > U mutations generate immunogenic peptides in SARS-CoV-2.Nature communications · 2025Article
- The role of asymptomatic infections in influenza transmission: what do we really know.The Lancet. Infectious diseases · 2024Review
- Source of SARS-CoV-2 infection: results from a series of 584,846 cases in France from October 2020 to August 2022.BMC public health · 2024Article
- Infectious disease surveillance needs for the United States: lessons from Covid-19.Frontiers in public health · 2024Review
- Review
- Asymptomatic but infectious - The silent driver of pathogen transmission. A pragmatic review.Epidemics · 2023Review
- The WE SENSE study protocol: A controlled, longitudinal clinical trial on the use of wearable sensors for early detection and tracking of viral respiratory tract infections.Contemporary clinical trials · 2023Article
- Intermediate levels of asymptomatic transmission can lead to the highest epidemic fatalities.PNAS nexus · 2023Article
- Data-driven approach in a compartmental epidemic model to assess undocumented infections.Chaos, solitons, and fractals · 2022Article
- Prioritizing interventions for preventing COVID-19 outbreaks in military basic training.PLoS computational biology · 2022Article
- Novel skewed usage of B-cell receptors in COVID-19 patients with various clinical presentations.Immunology letters · 2022Article
- Estimating and forecasting the burden and spread of Colombia's SARS-CoV2 first wave.Scientific reports · 2022Article
- Heterogeneous epidemic modelling within an enclosed space and corresponding Bayesian estimation.Infectious Disease Modelling · 2022Article
- Modelling COVID-19 outbreak on the Diamond Princess ship using the public surveillance data.Infectious Disease Modelling · 2022Article
- Role of Asymptomatic COVID-19 Cases in Viral Transmission: Findings From a Hierarchical Community Contact Network Model.IEEE transactions on automation science and engineering : a publication of the IEEE Robotics and Automation Society · 2022Article
- Contrasting SARS-CoV-2 epidemics in Singapore: cohort studies in migrant workers and the general population.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Unique Evolution of SARS-CoV-2 in the Second Large Cruise Ship Cluster in Japan.Microorganisms · 2022Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
A key unknown for SARS-CoV-2 is how asymptomatic infections contribute to transmission. We used a transmission model with asymptomatic and presymptomatic states, calibrated to data on disease onset and test frequency from the Diamond Princess cruise ship outbreak, to quantify the contribution of asymptomatic infections to transmission. The model estimated that 74% (70-78%, 95% posterior interval) of infections proceeded asymptomatically. Despite intense testing, 53% (51-56%) of infections remained undetected, most of them asymptomatic. Asymptomatic individuals were the source for 69% (20-85%) of all infections. The data did not allow identification of the infectiousness of asymptomatic infections, however low ranges (0-25%) required a net reproduction number for individuals progressing through presymptomatic and symptomatic stages of at least 15. Asymptomatic SARS-CoV-2 infections may contribute substantially to transmission. Control measures, and models projecting their potential impact, need to look beyond the symptomatic cases if they are to understand and address ongoing transmission.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.