ArticleeLife2020
Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- Methamphetamine potentiates the use of outcome-specific associations via a hypothalamic-dopamine circuit.Neuron · 2026Article
- Persistent representation of a prior schema in the orbitofrontal cortex facilitates learning of a conflicting schema.Nature communications · 2026Article
- Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microglia.Scientific reports · 2025Article
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- Divergent prefrontal cortex circuits regulate cued food seeking under distinct metabolic or emotional states.Nature communications · 2025Article
- Distinct contributions of anterior and posterior orbitofrontal cortex to outcome-guided behavior.bioRxiv : the preprint server for biology · 2025Article
- Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microglia.Research square · 2025Article
- Striatal dopamine signals errors in prediction across different informational domains.Science advances · 2025Article
- Projecting neurons from the lateral entorhinal cortex to the basolateral amygdala mediate the encoding of incidental odor-taste associations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The curious case of dopaminergic prediction errors and learning associative information beyond value.Nature reviews. Neuroscience · 2025Review
- Alterations of gray matter asymmetry in internet gaming disorder.Scientific reports · 2024Article
- The selective DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Dopamine Release in the Nucleus Accumbens Core Encodes the General Excitatory Components of Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Modeling impaired insight after drug use in rodents.Behavioral neuroscience · 2024Review
- Hippocampal and orbitofrontal neurons contribute to complementary aspects of associative structure.Nature communications · 2024Article
- Optogenetic Inhibition of Rat Anterior Cingulate Cortex Impairs the Ability to Initiate and Stay on Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- The cognitive (lateral) hypothalamus.Trends in cognitive sciences · 2024Review
- Lateral orbitofrontal cortex integrates predictive information across multiple cues to guide behavior.Current biology : CB · 2023Article
- Computationally Informed Interventions for Targeting Compulsive Behaviors.Biological psychiatry · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The orbitofrontal cortex (OFC) is necessary for inferring value in tests of model-based reasoning, including in sensory preconditioning. This involvement could be accounted for by representation of value or by representation of broader associative structure. We recently reported neural correlates of such broader associative structure in OFC during the initial phase of sensory preconditioning (Sadacca et al., 2018). Here, we used optogenetic inhibition of OFC to test whether these correlates might be necessary for value inference during later probe testing. We found that inhibition of OFC during cue-cue learning abolished value inference during the probe test, inference subsequently shown in control rats to be sensitive to devaluation of the expected reward. These results demonstrate that OFC must be online during cue-cue learning, consistent with the argument that the correlates previously observed are not simply downstream readouts of sensory processing and instead contribute to building the associative model supporting later behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.