Evidence map›Paper›PMID 32831171›Full record

ArticleeLife2020

Underground isoleucine biosynthesis pathways in

Charles Ar Cotton, Iria Bernhardsgrütter, Hai He, Simon Burgener, Luca Schulz, Nicole Paczia, Beau Dronsella, Alexander Erban, Stepan Toman, Marian Dempfle and 5 more

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Metabolic profiling of Escherichia coli under deuterium oxide-induced stress.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  2. Article
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  4. Article
  5. Article
  6. Article
  7. Effect of Light Regime onJournal of microbiology and biotechnology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. L-Proline Synthesis Mutants ofFrontiers in microbiology · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Setting the stage for evolution of a new enzyme.Current opinion in structural biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Charles Ar CottonMax Planck Institute of Molecular Plant Physiology, Potsdam, Germany.
Iria BernhardsgrütterMax Planck Institute for Terrestrial Microbiology, Marburg, Germany.ORCID 0000-0002-5019-8188
Hai HeMax Planck Institute of Molecular Plant Physiology, Potsdam, Germany.ORCID 0000-0003-1223-2813
Simon BurgenerMax Planck Institute for Terrestrial Microbiology, Marburg, Germany.ORCID 0000-0003-3703-168X
Luca SchulzMax Planck Institute for Terrestrial Microbiology, Marburg, Germany.
Nicole PacziaMax Planck Institute for Terrestrial Microbiology, Marburg, Germany.
Beau DronsellaMax Planck Institute of Molecular Plant Physiology, Potsdam, Germany.
Alexander ErbanMax Planck Institute of Molecular Plant Physiology, Potsdam, Germany.
Stepan TomanMax Planck Institute of Molecular Plant Physiology, Potsdam, Germany.
Marian DempfleMax Planck Institute of Molecular Plant Physiology, Potsdam, Germany.
Alberto De MariaMax Planck Institute of Molecular Plant Physiology, Potsdam, Germany.
Joachim KopkaMax Planck Institute of Molecular Plant Physiology, Potsdam, Germany.ORCID 0000-0001-9675-4883
Steffen N LindnerMax Planck Institute of Molecular Plant Physiology, Potsdam, Germany.ORCID 0000-0003-3226-3043
Tobias J ErbMax Planck Institute for Terrestrial Microbiology, Marburg, Germany.
Arren Bar-EvenMax Planck Institute of Molecular Plant Physiology, Potsdam, Germany.ORCID 0000-0002-1039-4328

Funding

Federal Ministry of Education and Research 031B0194 (FormatPlant)
6 · The paper itself

Abstract

The promiscuous activities of enzymes provide fertile ground for the evolution of new metabolic pathways. Here, we systematically explore the ability of

Indexed as

Gene DeletionButyratesCarbon-Oxygen LyasesEscherichia coliHomoserineIsoleucineMetabolic Networks and Pathwaysalpha-ketobutyric acidButyratesCarbon-Oxygen LyasesHomoserineIsoleucineO-succinylhomoserineO-succinylhomoserine (thiol)-lyasebiochemistrychemical biologyE. coliformate assimilationmethionine biosynthesispromiscuous enzymespyruvate formate-lyaseunderground metabolism

Identifiers

PMID32831171
PMCPMC7476758

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.