ArticleGenome biology2020
GBAT: a gene-based association test for robust detection of trans-gene regulation.
Article in Genome biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Machine learning and statistical methods for molecular quantitative trait loci.Nature reviews. Genetics · 2026Review
- Article
- Trans-regulation of heterochromatin underlies genetic variation in 3D genome contacts in mouse embryonic stem cells.Genome biology · 2026Article
- Protein-protein interactions shape trans-regulatory impact of genetic variation on protein expression and complex traits.Nature genetics · 2026Article
- Article
- Transcripts with high distal heritability mediate genetic effects on complex metabolic traits.Nature communications · 2025Article
- ADELLE: A global testing method for trans-eQTL mapping.PLoS genetics · 2025Article
- Trans-eQTL mapping in gene sets identifies network effects of genetic variants.Cell genomics · 2024Article
- Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits.American journal of human genetics · 2024Article
- SNRPD1 conveys prognostic value on breast cancer survival and is required for anthracycline sensitivity.BMC cancer · 2023Article
- Placental genomics mediates genetic associations with complex health traits and disease.Nature communications · 2022Article
- Gene-Level Germline Contributions to Clinical Risk of Recurrence Scores in Black and White Patients with Breast Cancer.Cancer research · 2022Article
- Article
- GBAT: a gene-based association test for robust detection of trans-gene regulation.Genome biology · 2020Article
- Efficient Estimation and Applications of Cross-Validated Genetic Predictions to Polygenic Risk Scores and Linear Mixed Models.Journal of computational biology : a journal of computational molecular cell biology · 2020Article
- A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits.American journal of human genetics · 2020Article
- Imputed gene associations identify replicable trans-acting genes enriched in transcription pathways and complex traits.Genetic epidemiology · 2019Article
- Adjusting for Principal Components of Molecular Phenotypes Induces Replicating False Positives.Genetics · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The observation that disease-associated genetic variants typically reside outside of exons has inspired widespread investigation into the genetic basis of transcriptional regulation. While associations between the mRNA abundance of a gene and its proximal SNPs (cis-eQTLs) are now readily identified, identification of high-quality distal associations (trans-eQTLs) has been limited by a heavy multiple testing burden and the proneness to false-positive signals. To address these issues, we develop GBAT, a powerful gene-based pipeline that allows robust detection of high-quality trans-gene regulation signal.
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