Evidence map›Paper›PMID 32831108›Full record

ArticleVirology journal2020

HLA-associated protection of lymphocytes during influenza virus infection.

Eliana E Ochoa, Ruksana Huda, Steven F Scheibel, Joan E Nichols, David J Mock, Nayef El-Daher, Frank M Domurat, Norbert J Roberts

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Eliana E OchoaDivision of Infectious Diseases, Department of Internal Medicine and the Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Ruksana HudaDivision of Infectious Diseases, Department of Internal Medicine and the Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Steven F ScheibelInfectious Diseases Unit, University of Rochester School of Medicine, Rochester, NY, USA.
Joan E NicholsDivision of Infectious Diseases, Department of Internal Medicine and the Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
David J MockInfectious Diseases Unit, University of Rochester School of Medicine, Rochester, NY, USA.
Nayef El-DaherInfectious Diseases Unit, University of Rochester School of Medicine, Rochester, NY, USA.
Frank M DomuratInfectious Diseases Unit, University of Rochester School of Medicine, Rochester, NY, USA.
Norbert J RobertsDivision of Infectious Diseases, Department of Internal Medicine and the Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. norbert.roberts@nyulangone.org.ORCID 0000-0002-4427-2986
University of Rochester · USThe University of Texas Medical Branch at Galveston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHeterozygosity at HLA class I loci is generally considered beneficial for host defense. We report here an element of HLA class I homozygosity that may or may not help preserve its existence in populations but which could indicate a new avenue for antiviral research.

methodsLymphocytes from serologically HLA-homozygous or -heterozygous donors were examined for synthesis of influenza virus proteins and RNA after exposure to virus as peripheral blood mononuclear cells. The virus-exposed lymphocytes were also examined for internalization of the virus after exposure, and for susceptibility to virus-specific cytotoxic T lymphocytes in comparison with virus-exposed monocytes/macrophages and unseparated peripheral blood mononuclear cells. Results were compared using two-tailed Fisher's exact test.

resultsSerologically-defined HLA-A2-homozygous lymphocytes, in contrast to heterozygous lymphocytes, did not synthesize detectable influenza virus RNA or protein after exposure to the virus. HLA-A2-homozygous lymphocytes, including both homozygous and heterozygous donors by genetic sequence subtyping, did internalize infectious virus but were not susceptible to lysis by autologous virus-specific cytotoxic T lymphocytes ("fratricide"). Similar intrinsic resistance to influenza virus infection was observed with HLA-A1- and HLA-A11-homozygous lymphocytes and with HLA-B-homozygous lymphocytes.

conclusionsA significant proportion of individuals within a population that is characterized by common expression of HLA class I alleles may possess lymphocytes that are not susceptible to influenza virus infection and thus to mutual virus-specific lysis. Further study may identify new approaches to limit influenza virus infection.

Indexed as

AllelesFemaleGenes, MHC Class IHLA-A11 AntigenHLA-A1 AntigenHLA-A2 AntigenHomozygoteHumansInfluenza, HumanLeukocytes, MononuclearMacrophagesMaleT-Lymphocytes, CytotoxicHLA-A11 AntigenHLA-A1 AntigenHLA-A2 AntigenHLAHomozygosityHuman leukocyte antigenHuman lymphocytesInfluenza virusMonocytes/macrophages

Identifiers

PMID32831108
PMCPMC7444183
OpenAlexW3080476310

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.