ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2020
Clinical and predictive value of simplified creatinine index used as muscle mass surrogate in end-stage kidney disease haemodialysis patients-results from the international MONitoring Dialysis Outcome initiative.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Lean tissue mass is associated with adverse outcomes across different stages of chronic kidney disease: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Modified creatinine index for predicting prognosis in hemodialysis patients: a systematic review and meta-analysis.Renal failure · 2024Pooled it
- Using a measurement type-independent metric to compare patterns of determinants between patient-reported versus performance-based physical function in hemodialysis patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Trial
- Developing an explainable machine learning model using body composition to predict cardiovascular mortality in initial dialysis patients: a multicenter study.Frontiers in physiology · 2026Article
- Malnutrition-inflammation-fluid overload complex syndrome and all-cause mortality in patients undergoing hemodialysisRenal failure · 2025Article
- Development and Investigation of a New Polysulfone Dialyzer with Increased Membrane Hydrophilicity.Membranes · 2025Review
- Comprehensive Insights into Sarcopenia in Dialysis Patients: Mechanisms, Assessment, and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2025Review
- The De Ritis ratio mediates the association between creatinine-to-body weight ratio and normoglycemic conversion in Chinese health examinees.Scientific reports · 2025Article
- Hand Grip Strength Index, a Novel Tool in Risk-Assessing Multi-Ethnic End-Stage Kidney Disease Patients Treated by Haemodialysis.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Article
- The Metabolism of Creatinine and Its Usefulness to Evaluate Kidney Function and Body Composition in Clinical Practice.Biomolecules · 2025Review
- Osteocalcin and Chinese visceral adiposity index are associated with the risk of ASCVD and arterial stiffness in patients with T2DM.Scientific reports · 2024Article
- Importance of dialysis specialists in early mortality in elderly hemodialysis patients: a multicenter retrospective cohort study.Scientific reports · 2024Article
- Simplified Creatinine Index as Predictor of Malnutrition in Stage 5 Chronic Kidney Disease Patients on Maintenance Haemodialysis.International journal of nephrology and renovascular disease · 2024Article
- Physical performance tasks were linked to the PROMIS physical function metric in patients undergoing hemodialysis.Journal of clinical epidemiology · 2023Article
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- Association of the modified creatinine index with muscle strength and mortality in patients undergoing hemodialysis.Renal failure · 2022Article
- Simplified discriminant parameters for sarcopenia among patients undergoing haemodialysis.Journal of cachexia, sarcopenia and muscle · 2022Article
- Personalizing treatment in end-stage kidney disease: deciding between haemodiafiltration and haemodialysis based on individualized treatment effect prediction.Clinical kidney journal · 2022Article
- Impact of Hydrophilic Modification of Synthetic Dialysis Membranes on Hemocompatibility and Performance.Membranes · 2022Review
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Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProtein-energy wasting, muscle mass (MM) loss and sarcopenia are highly prevalent and associated with poor outcome in haemodialysis (HD) patients. Monitoring of MM and/or muscle metabolism in HD patients is of paramount importance for timely detection of muscle loss and to intervene adequately. In this study we assessed the reliability and reproducibility of a simplified creatinine index (SCI) as a surrogate marker of MM and explored its predictive value on outcome.
methodWe included all in-centre HD patients from 16 European countries with at least one SCI. The baseline period was defined as 30 days before and after the first multifrequency bioimpedance spectroscopy measurement; the subsequent 7 years constituted the follow-up. SCI was calculated by the Canaud equation. Multivariate Cox proportional hazards models were applied to assess the association of SCI with all-cause mortality. Using backward analysis, we explored the trends of SCI before death. Bland-Altman analysis was performed to analyse the agreement between estimated and measured MM.
resultsWe included 23 495 HD patients; 3662 were incident. Females and older patients have lower baseline SCI. Higher SCI was associated with a lower risk of mortality [hazard ratio 0.81 (95% confidence interval 0.79-0.82)]. SCI decline accelerated ∼5-7 months before death. Lean tissue index (LTI) estimated by SCI was correlated with measured LTI in both sexes (males: R2 = 0.94; females: R2 = 0.92; both P < 0.001). Bland-Altman analysis showed that measured LTI was 4.71 kg/m2 (±2 SD: -12.54-3.12) lower than estimated LTI.
conclusionSCI is a simple, easily obtainable and clinically relevant surrogate marker of MM in HD patients.
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