ArticleBritish journal of cancer2020
Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration.
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Article in British journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 5 of them syntheses that pooled it.
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72citing papers in PubMed, 5 pooled it
11.6field-weighted citation impact, top 1% of its field
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Who cites it
72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Association between tonsillectomy and risk of oropharyngeal cancer: a systematic review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024Pooled it
- Deep learning algorithm performance in contouring head and neck organs at risk: a systematic review and single-arm meta-analysis.Biomedical engineering online · 2023Pooled it
- Characteristics and outcomes of transoral robotic surgery with free-flap reconstruction for oropharyngeal cancer: a systematic review.Journal of robotic surgery · 2023Pooled it
- The Use of Contrast-Enhanced Sonography for Therapy Monitoring of Metastatic Lymph Nodes: A Systematic Review.Current oncology (Toronto, Ont.) · 2023Pooled it
- Comparison of tobacco and alcohol consumption in young and older patients with oral squamous cell carcinoma: a systematic review and meta-analysis.Clinical oral investigations · 2022Pooled it
- Development and validation of a nomogram to predict cancer-specific survival in patients with hypopharyngeal squamous cell carcinoma treated with primary surgery.The Journal of international medical research · 2021Trial
- Implementing an evidence-based model of pre-operative nutrition care in patients undergoing oral cavity reconstruction surgery for head and neck cancer: a feasibility study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Trends and Drivers of Head and Neck Cancers in Older Adults Over 30 Years: A Population-Based Modelling Study.Risk management and healthcare policy · 2026Article
- A New Orthotopic Mouse Model of Laryngeal Squamous Cell Carcinoma.Head & neck · 2026Article
- Cellular Senescence as a Risk Factor in Head and Neck Cancer-Diagnostic and Therapeutic Perspective.Cancers · 2025Review
- Alcohol consumption and upper aerodigestive tract squamous cell carcinoma: evidence from 28 prospective cohorts.Journal of the National Cancer Institute · 2025Article
- Article
- First-Line Therapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Retrospective, Multicenter, Real-World Study.Head & neck · 2025Article
- Occupations and Risk of Head and Neck Cancers: A Case-Control Study in Tanzania.International journal of environmental research and public health · 2025Article
- A systematic review and network meta-analysis of therapies for locally advanced head and neck squamous cell carcinoma with different HPV status.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025Review
- Radiation therapy response prediction for head and neck cancer using multimodal imaging and multiview dynamic graph autoencoder feature selection.Medical physics · 2025Article
- Liquid Biopsy's Role in Head and Neck Tumors: Changing Paradigms in the Era of Precision Medicine.Diagnostics (Basel, Switzerland) · 2025Review
- Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study.Discover oncology · 2025Article
- Assessing Efficacy of Interleukin-1 Blockade in Patients with Alcoholic Hepatitis: A Comprehensive Systematic Review of Emerging Evidence.Life (Basel, Switzerland) · 2025Review
- Association of Gene Expression Profiles in HPV-Positive Head and Neck Squamous Cell Carcinoma with Patient Outcome: In Search of Prognostic Biomarkers.International journal of molecular sciences · 2025Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
63 authors at 20 institutions in 18 countries.
Gioia Di CredicoDepartment of Economics, Business, Mathematics and Statistics, University of Trieste, Trieste, Italy.
Jerry PoleselCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. polesel@cro.it.
Luigino Dal MasoCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. epidemiology@cro.it.
Francesco PauliDepartment of Economics, Business, Mathematics and Statistics, University of Trieste, Trieste, Italy.
Nicola TorelliDepartment of Economics, Business, Mathematics and Statistics, University of Trieste, Trieste, Italy.
Daniele LuceUniversité de Rennes, INSERM, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), UMR_S 1085, Pointe-à-Pitre, France.
Loredana RadoïINSERM UMR 1018, Centre for Research in Epidemiology and Population Health (CESP), Cancer Epidemiology, Genes and Environment Team, Villejuif, France.
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Diego SerrainoCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
Paul BrennanInternational Agency for Research on Cancer, Lyon, France.
Ivana HolcatovaInstitute of Hygiene & Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Wolfgang AhrensLeibniz Institute for Prevention Research and Epidemiology, BIPS, Bremen, Germany.
Pagona LagiouDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Cristina CanovaUniversity of Padua, Padova, Italy.
Lorenzo RichiardiDepartment of Medical Sciences, University of Turin, Turin, Italy.ORCID http://orcid.org/0000-0003-0316-9402
Claire M HealyTrinity College School of Dental Science, Dublin, Ireland.
Kristina KjaerheimCancer Registry of Norway, Oslo, Norway.
David I ConwaySchool of Medicine, Dentistry, and Nursing, University of Glasgow, Glasgow, UK.
Gary J MacfarlaneSchool of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
Peter ThomsonUniversity of Hong Kong, Hong Kong, China.
Antonio AgudoUnit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08908, Spain.
Ariana ZnaorInternational Agency for Research on Cancer, Lyon, France.
Silvia FranceschiScientific Directorate, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
Rolando HerreroInternational Agency for Research on Cancer, Lyon, France.
Tatiana N ToporcovDepartment of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil.
Raquel A MoysesHead and Neck Surgery, School of Medicine, University of São Paulo, São Paulo, Brazil.
Joshua MuscatPenn State College of Medicine, Hershey, PA, USA.
Eva NegriDepartment of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Marta VilenskyInstituto de Oncología Ángel H. Roffo, Universidad de Buenos Aires, Buenos Aires, Argentina.
Leticia FernandezInstitute of Oncology and Radiobiology, Havana, Cuba.
Maria Paula CuradoEpidemiology-CIPE/ACCAMARGO, Sao Paulo, Brazil.
Ana MenezesUniversidade Federal de Pelotas, Pelotas, Brazil.
Alexander W DaudtHospital Moinhos de Vento, Porto Alegre, Brazil.
Rosalina KoifmanEscola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
Victor Wunsch-FilhoDepartment of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil.
Andrew F OlshanDepartment of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC, USA.
Jose P ZevallosDivision of Head and Neck Surgical Oncology in the Department of Otolaryngology/Head and Neck Surgery at Washington University School of Medicine, St Louis, MO, USA.
Erich M SturgisDepartment of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA.
Guojun LiDepartment of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA.
Fabio LeviInstitut Universitaire de Médecine Sociale et Préventive (IUMSP), Unisanté, University of Lausanne, Lausanne, Switzerland.
Zuo-Feng ZhangUCLA School of Public Health, Los Angeles, CA, USA.
Hal MorgensternDepartments of Epidemiology and Environmental Health Sciences, School of Public Health and Department of Urology, Medical School, University of Michigan, Ann Arbor, MI, USA.
Elaine SmithCollege of Public Health, University of Iowa, Iowa City, IA, USA.
Philip LazarusDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.
Carlo La VecchiaBranch of Medical Statistics, Biometry and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy.
Werner GaravelloDepartment of Otorhinolaryngology, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Chu ChenProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Stephen M SchwartzProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Tongzhang ZhengDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Thomas L VaughanProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Karl KelseyBrown University, Providence, Rhode Island, RI, USA.
Michael McCleanBoston University School of Public Health, Boston, MA, USA.
Simone BenhamouNational Institute of Health and Medical Research, INSERM U1018, Villejuif, France.
Richard B HayesDivision of Epidemiology, New York University School Of Medicine, New York, NY, USA.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Maura Gillison"Thoracic/Head and Neck Medical Oncology", The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Stimson SchantzNew York Eye and Ear Infirmary, New York, NY, USA.
Guo-Pei YuMedical Informatics Center, Peking University, Beijing, China.
Shu-Chun ChuangInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Paolo BoffettaDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Mia HashibeDivision of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, UT, USA.
Amy Lee Yuan-ChinDivision of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, UT, USA.
Valeria EdefontiBranch of Medical Statistics, Biometry and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy.
Centro di Riferimento Oncologico · ITCentre international de recherche sur le cancer · FRFred Hutch Cancer Center · USInserm · FRUniversidade de São Paulo · BRUniversity of Milan · ITUniversity of Trieste · ITBaylor College of Medicine · USBrown University · USUniversity of Utah · USAC Camargo Hospital · BRAichi Cancer Center · JPBoston University · USCancer Registry of Norway · NOCharles University · CZEscola Nacional de Saúde Pública · BRHospital Moinhos de Vento · BRInstitut d'Investigació Biomédica de Bellvitge · ESInstitute of Social and Preventive Medicine · CHInstituto de Oncología y Radiobiología · CU
Funding
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MUCLA SPORE IN LUNG CANCERP50CA090388 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2001 to 2008
$13.0MUDP GLUCURONOSYLTRANSFERASES, DETOXIFICATION OF NNKP01CA068384 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LAZARUS, PHILIP · 1995 to 2005
$8.5MSYNTHETIC STUDIES RELATED TO CANCER RESEARCH/TREATMENTR01CA031845 · NCI · STANFORD UNIVERSITY · PI PAUL Anthony WENDER · 1985 to 2026
$6.9MUCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3MThe Boston Collaborative Oral Cancer StudyR01CA078609 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 1999 to 2010
$5.3MLUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERSU01CA096134 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAO, JENNY T · 2002 to 2007
$5.1MGene Environment Interaction in Head and Neck CancerR01CA090731 · NCI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI OLSHAN, ANDREW · 2001 to 2005
$4.6MUDPGLUCURONOSYLTRANSFERASE GENOTYPE AND ORAL CANCER RISKR01DE013158 · NIDCR · UNIVERSITY OF SOUTH FLORIDA · PI LAZARUS, PHILIP · 2000 to 2011
$3.6MThe Oral Microbiome and Upper Aerodigestive Squamous Cell CancerR01CA159036 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI AHN, JIYOUNG, HAYES, RICHARD BERNARD · 2011 to 2024
$3.5MProject 2P20CA252728 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI AHN, JIYOUNG · 2020 to 2022
$3.4MDual CHIP Functions Control Tau Triage In Alzheimer's DiseaseR01AG061188 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COHEN, TODD JONATHAN, SCHISLER, JONATHAN C. · 2019 to 2023
$3.1MNCI NIH HHS K07 CA104231NCI NIH HHS P01 CA068384NCI NIH HHS P20 CA252728NCI NIH HHS P50 CA090388NCI NIH HHS R01 CA030022NCI NIH HHS R01 CA031845NCI NIH HHS R01 CA048996NCI NIH HHS R01 CA078609NCI NIH HHS R01 CA090731NCI NIH HHS R01 CA100679NCI NIH HHS R01 CA159036NCI NIH HHS R03 CA077954NCI NIH HHS R03 CA113157NCI NIH HHS T32 CA009142NCI NIH HHS U01 CA096134NIA NIH HHS R01 AG061188NIDA NIH HHS R01 DA011386NIDA NIH HHS R01 DA011979NIDA NIH HHS R01 DA012609NIDCR NIH HHS R01 DE013110NIDCR NIH HHS R01 DE013158NIDCR NIH HHS R03 DE016611NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R21 ES011667World Health Organization 001
Abstract
backgroundAlcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.
methodsData from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking.
resultsFor all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx).
conclusionsPresent results further encourage the reduction of alcohol intensity to mitigate HNC risk.
Indexed as
AdolescentAdultAgedAged, 80 and overAlcohol DrinkingCase-Control StudiesFemaleHead and Neck NeoplasmsHumansLaryngeal NeoplasmsMaleMiddle AgedMouth NeoplasmsOropharyngeal NeoplasmsRisk FactorsSeverity of Illness Index
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