ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2020
Gold Microstructures/Polyaniline/Reduced Graphene Oxide/Prussian Blue Composite as Stable Redox Matrix for Label-free Electrochemical Immunoassay of α-Fetoprotein.
Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma.Biosensors · 2024Review
- Highly Sensitive Immunosensing of Carcinoembryonic Antigen Based on Gold Nanoparticles Dotted PB@PANI Core-Shell Nanocubes as a Signal Probe.Journal of analytical methods in chemistry · 2023Article
- Electrochemical analysis based on bioaffinity.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2022Article
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5 authors at 1 institution in 1 country.
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Abstract
Sensitivity amplification strategies in label-free electrochemical immunosensors are mainly limited by redox molecules leaking and degradation of electrical conductivity caused by layers of decoration. Herein, a relatively stable and sensitive label-free electrochemical immunosensor based on a hierarchically flower-like gold microstructures/polyaniline/reduced graphene oxide/prussian blue (HFG/PANI/rGO/PB) composite modified electrode was stepwise fabricated for determination of α-fetoprotein (AFP). In this process, the effect of PANI and rGO on the proposed immunosensor was studied. In detail, PANI/rGO due to the unique electrochemical properties can effectively prevent PB leakage and form a stable sensing platform, which causes sensitive responsiveness and thus a more satisfied detection limit. Meanwhile, the HFG with good biological compatibility can effectively immobilize plenty of antibodies. Under optimal conditions, the HFG/PANI/rGO/PB modified immunosensor exhibited an excellent linearity (0.01 - 30 ng/mL) and a low detection limit (0.003 ng/mL) (S/N = 3), suitable specificity as well as stability and reproducibility towards AFP. The present work offered a promising platform for clinical hepatocellular carcinoma diagnostics.
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Registered trials
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