ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Reduced Activation in the Pallidal-Thalamic-Motor Pathway Is Associated With Deficits in Reward-Modulated Inhibitory Control in Adults With a History of Attention-Deficit/Hyperactivity Disorder.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Distinct neurobiological alterations during hedonic experience of rewards in attention deficit hyperactivity disorder and autism spectrum disorder: Multimodal evidence from neuroimaging meta-analyses.Molecular psychiatry · 2026Pooled it
- [The sensorimotor domain in the research domain criteria system: progress and perspectives].Der Nervenarzt · 2021Pooled it
- Nicotine Exposure During Gestation: From Placental Dysfunction to Long-Term Neurobehavioral Outcomes.Birth defects research · 2026Review
- Decoding gene networks controlling hypothalamic and prethalamic neuron development.Cell reports · 2025Article
- Decoding Gene Networks Controlling Hypothalamic and Prethalamic Neuron Development.bioRxiv : the preprint server for biology · 2025Article
- Altered Lateral Prefrontal Cortex Functioning During Emotional Interference Resistance Is Associated With Affect Lability in Adults With Persisting Symptoms of Attention-Deficit/Hyperactivity Disorder From Childhood.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches.Psychiatry research · 2024Article
- The rostral intralaminar nuclear complex of the thalamus supports striatally mediated action reinforcement.eLife · 2023Article
- Is genetic risk of ADHD mediated via dopaminergic mechanism? A study of functional connectivity in ADHD and pharmacologically challenged healthy volunteers with a genetic risk profile.Translational psychiatry · 2022Article
- Smoking-Specific Risk Factors in Early Adulthood That Mediate Risk of Daily Smoking by Age 29 for Children with ADHD.Journal of attention disorders · 2022Article
- Rostral Intralaminar Thalamus Engagement in Cognition and Behavior.Frontiers in behavioral neuroscience · 2021Review
- Analysis of risk factors for Meige syndrome and construction and validation of a clinical prediction nomogram model.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAttention-deficit/hyperactivity disorder (ADHD) symptoms persist into adulthood and are associated with functional impairments. Neuroimaging studies of reward-modulated inhibitory control can identify potential objective markers of impairment and may deepen our understanding of why probands engage in costly behaviors leading to adverse outcomes. The study aimed to identify reward-modulated inhibitory control neural circuitries, their association with ADHD symptoms, and real-world implications of a decreased capacity to engage in reward-modulated inhibitory control.
methodsA total of 106 adults (90% male) with rigorous childhood diagnoses of ADHD were scanned with functional magnetic resonance imaging during the Monetary Incentive Go/NoGo task. Adulthood symptoms of inattention and hyperactivity/impulsivity based on self- and informant report were assessed. The number of lifetime attempts taken to quit smoking were also assessed as an exemplar real-world outcome.
resultsHyperactivity/impulsivity was negatively associated with activation in the pallidum and primary motor cortex when inhibiting a previously rewarded Go stimulus that yielded a small immediate reward in order to obtain a larger reward later on. Reduced recruitment of the pallidal-thalamic-motor circuit mediated the negative association between hyperactivity/impulsivity and reward-modulated inhibitory control accuracy. Reduced pallidum activation, in response to reward-modulated inhibitory control, was also associated with more attempts made to successfully quit smoking.
conclusionsProbands with persistent hyperactivity/impulsivity symptoms have alterations in brain regions that calculate the value of inhibiting an action that yields an immediate reward in order to obtain delayed larger rewards. This deficit results in poor inhibitory control on basic tasks and during real-world behaviors that rely on similar processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.