Evidence map›Paper›PMID 32829908›Full record

ArticleMayo Clinic proceedings2020

Utility of HAS-BLED and CHA

Robert Ward, Shiva Ponamgi, Christopher V DeSimone, Stephen English, David O Hodge, Joshua P Slusser, Jonathan Graff-Radford, Alejandro A Rabinstein, Samuel J Asirvatham, David Holmes

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Article in Mayo Clinic proceedings, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Robert WardDivision of Internal Medicine, Mayo Clinic, Rochester, MN.
Shiva PonamgiDivision of Hospital Internal Medicine, Mayo Clinic, Rochester, MN.
Christopher V DeSimoneDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
Stephen EnglishDepartment of Neurology, Emory University, Atlanta, GA.
David O HodgeDepartment of Health Sciences Research, Mayo Clinic, Jacksonville, FL.
Joshua P SlusserDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN.
Jonathan Graff-RadfordDepartment of Neurology, Mayo Clinic, Rochester, MN.
Alejandro A RabinsteinDepartment of Neurology, Mayo Clinic, Rochester, MN.
Samuel J AsirvathamDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN; Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, MN.
David HolmesDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
Mayo Clinic in Arizona · USMayo Clinic in Florida · USEmory University · US

Funding

Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
NIA NIH HHS R01 AG034676
6 · The paper itself

Abstract

objectiveTo determine the utility of the HAS-BLED (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly, Drugs/alcohol concomitantly) and CHA PATIENTS AND

methodsPatients older than 55 years with a diagnosis of AF who had a nontraumatic intracerebral hemorrhage (ICH) while on AC therapy between 1995 and 2016 were identified using the Rochester Epidemiology Project Database. Medical records were reviewed, including imaging of the brain, to identify baseline characteristics, AC use, and outcomes.

resultsA total of 65 patients were identified (mean age, 81.3 years); 35 (53.8%) had evidence of possible/probable CAA. Mean HAS-BLED score in the CAA group was significantly lower (2.1) than that of the non-CAA group (2.9; P<.001). Mortality after ICH, adjusted for HAS-BLED scores, was not significantly different among patients with and without CAA. Sixteen patients restarted on AC therapy after ICH; CHA

conclusionHAS-BLED scores were lower in patients who had evidence of CAA compared with those without, suggesting underestimation of ICH risk in patients with CAA. CHA

Indexed as

AgedAged, 80 and overAnticoagulantsAtrial FibrillationCerebral Amyloid AngiopathyFemaleHumansIntracranial HemorrhagesMagnetic Resonance ImagingMaleRetrospective StudiesRisk AssessmentRisk FactorsStrokeTomography, X-Ray ComputedAnticoagulants

Identifiers

PMID32829908
PMCPMC8635034
OpenAlexW3064229163

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.