ArticleParasitology2021
Further studies of neuroangiostrongyliasis (rat lungworm disease) in Australian dogs: 92 new cases (2010-2020) and results for a novel, highly sensitive qPCR assay.
Article in Parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- The 90th anniversary of Angiostrongylus cantonensis: from local discovery to global endemic.Infectious diseases of poverty · 2025Article
- Evidence of new endemic foci of the foodborne helminths Angiostrongylus spp. in rats in selected communities in the Philippines.Parasites & vectors · 2025Article
- Same parasite, diverging fates: distinct responses of tenrecs to Angiostrongylus cantonensis infection.Veterinary research communications · 2025Article
- Rainfall- and Temperature-Driven Emergence of Neural Angiostrongyliasis in Eastern Australia, 2020-2024.The Journal of infectious diseases · 2025Article
- Living in the city: Angiostrongylus cantonensis is a novel threat to an urban population of Florida burrowing owls (Athene cunicularia floridana) in south Florida.Parasites & vectors · 2025Article
- Detection of rat lungworm (Angiostrongylus cantonensis) infection by real-time PCR from the peripheral blood of animals: a preliminary study.Parasitology research · 2024Article
- Older urban rats are infected with the zoonotic nematodeCurrent research in parasitology & vector-borne diseases · 2024Article
- Fatal neural angiostrongyliasis in the Bolivian squirrel monkey (One health (Amsterdam, Netherlands) · 2023Article
- Angie-LAMP for diagnosis of human eosinophilic meningitis using dog as proxy: A LAMP assay for Angiostrongylus cantonensis DNA in cerebrospinal fluid.PLoS neglected tropical diseases · 2023Article
- Successful Removal ofPathogens (Basel, Switzerland) · 2023Article
- Paratenic hosts ofOne health (Amsterdam, Netherlands) · 2022Review
- Angiostrongylosis in Animals and Humans in Europe.Pathogens (Basel, Switzerland) · 2021Review
- Magnetic resonance imaging in dogs with neuroangiostrongyliasis (rat lungworm disease).Parasitology · 2021Article
- Article
- Using cerebrospinal fluid to confirmCurrent research in parasitology & vector-borne diseases · 2021Article
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The principal aim of this study was to optimize the diagnosis of canine neuroangiostrongyliasis (NA). In total, 92 cases were seen between 2010 and 2020. Dogs were aged from 7 weeks to 14 years (median 5 months), with 73/90 (81%) less than 6 months and 1.7 times as many males as females. The disease became more common over the study period. Most cases (86%) were seen between March and July. Cerebrospinal fluid (CSF) was obtained from the cisterna magna in 77 dogs, the lumbar cistern in f5, and both sites in 3. Nucleated cell counts for 84 specimens ranged from 1 to 146 150 cells μL-1 (median 4500). Percentage eosinophils varied from 0 to 98% (median 83%). When both cisternal and lumbar CSF were collected, inflammation was more severe caudally. Seventy-three CSF specimens were subjected to enzyme-linked immunosorbent assay (ELISA) testing for antibodies against A. cantonensis; 61 (84%) tested positive, titres ranging from <100 to ⩾12 800 (median 1600). Sixty-one CSF specimens were subjected to real-time quantitative polymerase chain reaction (qPCR) testing using a new protocol targeting a bioinformatically-informed repetitive genetic target; 53/61 samples (87%) tested positive, CT values ranging from 23.4 to 39.5 (median 30.0). For 57 dogs, it was possible to compare CSF ELISA serology and qPCR. ELISA and qPCR were both positive in 40 dogs, in 5 dogs the ELISA was positive while the qPCR was negative, in 9 dogs the qPCR was positive but the ELISA was negative, while in 3 dogs both the ELISA and qPCR were negative. NA is an emerging infectious disease of dogs in Sydney, Australia.
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