Evidence map›Paper›PMID 32829672›Full record

ArticleJournal of neurotrauma2021

Accelerated Failure Time Survival Model to Analyze Morris Water Maze Latency Data.

Clark R Andersen, Jordan Wolf, Kristofer Jennings, Donald S Prough, Bridget E Hawkins

Abstract read
In one paragraph

Article in Journal of neurotrauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Clark R AndersenThe Moody Project for Translational Traumatic Brain Injury Research, University of Texas Medical Branch, Galveston, Texas, USA.
Jordan WolfThe Moody Project for Translational Traumatic Brain Injury Research, University of Texas Medical Branch, Galveston, Texas, USA.
Kristofer JenningsOffice of Biostatistics, Department of Preventive Medicine and Population Health, University of Texas Medical Branch, Galveston, Texas, USA.
Donald S ProughThe Moody Project for Translational Traumatic Brain Injury Research, University of Texas Medical Branch, Galveston, Texas, USA.
Bridget E HawkinsThe Moody Project for Translational Traumatic Brain Injury Research, University of Texas Medical Branch, Galveston, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) induces cognitive deficits clinically and in animal models. Learning and memory testing is critical when evaluating potential therapeutic strategies and treatments to manage the effects of TBI. We evaluated three data analysis methods for the Morris water maze (MWM), a learning and memory assessment widely used in the neurotrauma field, to determine which statistical tool is optimal for MWM data. Hidden platform spatial MWM data aggregated from three separate experiments from the same laboratory were analyzed using 1) a logistic regression model, 2) an analysis of variance (ANOVA) model, and 3) an accelerated failure time (AFT) time-to-event model. The logistic regression model showed no significant evidence of differences between treatments among any swims over all days of the study,

Indexed as

AnimalsBrain Injuries, TraumaticCerebral CortexDisease Models, AnimalMaleMorris Water Maze TestRatsRats, Sprague-DawleySpatial Memorylatencylearning and memoryMorris water mazesurvival analysistraumatic brain injury

Identifiers

PMID32829672
PMCPMC7875609

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.