Evidence map›Paper›PMID 32829665›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Alkaline Phosphatase Activity Is a Key Determinant of Vascular Responsiveness to Norepinephrine.

Edwin K Jackson, Dongmei Cheng, Vladimir B Ritov, Zaichuan Mi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Effects and Mechanism of 2'-AMP on Renal Vascular Resistance: Role of P2X1 Receptors.Journal of the American Society of Nephrology : JASN · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. ADRA1A-GαNature metabolism · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Edwin K JacksonFrom the Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, PA.
Dongmei ChengFrom the Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, PA.
Vladimir B RitovFrom the Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, PA.
Zaichuan MiFrom the Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, PA.
University of Pittsburgh · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Role of Renal Dipeptidyl Peptidase IVR01HL069846 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2003 to 2020
$6.6M
The Guanosine-Adenosine MechanismR01HL109002 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2012 to 2023
$5.1M
The Renal 2',3'-cAMP-Adenosine PathwayR01DK068575 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2005 to 2016
$4.0M
Adenosine in Renal Sympathetic NeurotransmissionR01DK091190 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2011 to 2020
$3.4M
NHLBI NIH HHS R01 HL069846NHLBI NIH HHS R01 HL109002NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK068575NIDDK NIH HHS R01 DK091190
6 · The paper itself

Abstract

Here, we tested the hypothesis that TNAP (tissue nonspecific alkaline phosphatase) modulates vascular responsiveness to norepinephrine. In the isolated, Tyrode's-perfused rat mesentery, 50 µmol/L of L-p-bromotetramisole (L-p-BT; selective TNAP inhibitor, K

Indexed as

Adenosine A1 Receptor AntagonistsAlkaline PhosphataseAnimalsMaleMembrane ProteinsMesenteryNorepinephrineRatsTetramisoleVasoconstrictionVasoconstrictor AgentsXanthines1,3-dipropyl-8-cyclopentylxanthine4-bromotetramisoleAdenosine A1 Receptor AntagonistsAlkaline PhosphataseAlpl protein, ratMembrane ProteinsNorepinephrineTetramisoleVasoconstrictor AgentsXanthinesadenosineadenosine A1 receptoralkaline phosphatasemesenterynorepinephrineratvasoconstriction

Identifiers

PMID32829665
PMCPMC7484402
OpenAlexW3080651815

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.