ArticleHypertension (Dallas, Tex. : 1979)2020
Microdissection of the Human Renal Nervous System: Implications for Performing Renal Denervation Procedures.
Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Aorticorenal Ganglion Ablation Enhances Blood Pressure Reduction After Renal Denervation.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- Catheter-Based Renal Denervation in Uncontrolled and Resistant Hypertension: Evidence, Guidelines, Special Populations and Clinical Implementation.Journal of cardiovascular development and disease · 2026Review
- A novel laparoscopic renal denervation system in a preclinical swine model.Scientific reports · 2026Article
- Overcoming variable response in renal denervation: Key strategies for reliable clinical implementation.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Addressing Hypertension Treatment Disparities Via Renal Denervation.Current hypertension reports · 2026Review
- Renal Denervation in Asia: 2025 Asia Renal Denervation Consortium (ARDeC) Consensus Statement Endorsed by the Hypertension Cardiovascular Outcome Prevention and Evidence in Asia (HOPE Asia) Network.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Renal denervation is effective in reducing blood pressure in patients with CKD.Clinical kidney journal · 2025Review
- Renal nerves in physiology, pathophysiology and interoception.Nature reviews. Nephrology · 2025Review
- An Update on the Role of Renal Artery Denervation in the Treatment of Hypertension.Current treatment options in cardiovascular medicine · 2025Article
- Catheter-Based Renal Denervation for Resistant Arterial Hypertension: 10-Year Real-World Follow-Up Data.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Opportunities and Limitations of Renal Denervation: Where Do We Stand?The American journal of medicine · 2024Review
- Relationship between Lesion Parameters after Radiofrequency Catheter Ablation in Striated Muscles and Parenchymal Tissue.Medicina (Kaunas, Lithuania) · 2024Article
- Computed tomographic manifestations of celiac ganglia between hypertensive and non-hypertensive population.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Effect of renal denervation for patients with isolated systolic hypertension: a systematic review and meta-analysis.Journal of geriatric cardiology : JGC · 2023Article
- Translational value of preclinical models for renal denervation: a histological comparison of human versus porcine renal nerve anatomy.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023Article
- Reply.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Beyond the Anatomy of Renal Nerves: Functional Diversity of Renal Nerves.Journal of cardiovascular translational research · 2022Article
- Present Evidence of Determinants to Predict the Efficacy of Renal Denervation.International journal of hypertension · 2022Review
- Immediate Renal Denervation After Acute Myocardial Infarction Mitigates the Progression of Heart Failure via the Modulation of IL-33/ST2 Signaling.Frontiers in cardiovascular medicine · 2021Article
- Device-Based Sympathetic Nerve Regulation for Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2021Review
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the use of renal denervation to treat hypertension, the anatomy of the renal nervous system remains poorly understood. We performed a detailed quantitative analysis of the human renal nervous system anatomy with the goal of optimizing renal denervation procedural safety and efficacy. Sixty kidneys from 30 human cadavers were systematically microdissected to quantify anatomic variations in renal nerve patterns. Contrary to current clinical perception, not all renal innervation followed the main renal artery. A significant portion of the renal nerves (late arriving nerves) frequently reached the kidney (73% of the right kidney and 53% of the left kidney) bypassing the main renal artery. The ratio of the main renal artery length/aorta-renal hilar distance proved to be a useful variable to identify the presence/absence of these late arriving nerves (odds ratio, 0.001 (95% CI, 0.00002-0.0692;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.