Evidence map›Paper›PMID 32829511›Full record

SynthesisDermatologic therapy2020

Effect of immunosuppressive drugs in immune-mediated inflammatory disease during the coronavirus pandemic.

Federica Giuliani, Giulio Gualdi, Paolo Amerio

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Dermatologic therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Federica GiulianiClinical Research Center-CAST, Center for Advanced Science and Technology, "G. d'Annunzio" Foundation, Chieti, Italy.ORCID https://orcid.org/0000-0003-3570-4027
Giulio GualdiClinical Research Center-CAST, Center for Advanced Science and Technology, "G. d'Annunzio" Foundation, Chieti, Italy.ORCID https://orcid.org/0000-0002-1640-6609
Paolo AmerioClinical Research Center-CAST, Center for Advanced Science and Technology, "G. d'Annunzio" Foundation, Chieti, Italy.ORCID https://orcid.org/0000-0003-1589-9672
University of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The safety of immunosuppressive treatment in patients with Immune-Mediated Inflammatory Diseases (IMIDs) during the Coronavirus pandemic is questioned and it is utmost important for public health. We searched studies trough MEDLINE/EMBASE database, including patient with IMID, undergoing immunosuppressive treatment with a positive diagnosis for SARS-CoV 2. We included 11 studies for the descriptive analysis and 10 studies for the pooled analysis, with a total population of 57 and 53 IMID-affected SARS-CoV-positive patients respectively. Overall no death was reported; 16 patients were hospitalized (30.2%) and only two cases were admitted to Intensive Care Unit (ICU) (3.8%). We found a significant association between the risk of hospitalization and older age (P .03), obesity (P .02), and presence of multi-comorbidity (P .03). No significant association was found between the risk of hospitalization and the use of biological or conventional DMARDs (respectively P .32 and .26), neither when they are used combined (P .85). We found consistent results in the sub-analysis of Psoriasis: 10 patients were hospitalized (31.3%) and only one case was admitted to Intensive Care Unit (ICU) (3.1%) Particular attention should be placed for patients with older age, obesity and multi-comorbidity that are at higher risk of hospitalization.

Indexed as

AdultAgedAge FactorsAntirheumatic AgentsBiological ProductsCOVID-19FemaleHospitalizationHost-Pathogen InteractionsHumansImmunocompromised HostImmunosuppressive AgentsInflammationMaleMiddle AgedMultimorbidityAntirheumatic AgentsBiological ProductsImmunosuppressive Agentsbiologiccoronavirusimmune-mediate inflammatory diseaseimmunosuppressive drugspsoriasis

Identifiers

PMID32829511
PMCPMC7461363
OpenAlexW3080488546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.