Evidence map›Paper›PMID 32829453›Full record

ReviewMolecular neurobiology2020

Gut Microbiota and Dysbiosis in Alzheimer's Disease: Implications for Pathogenesis and Treatment.

Shan Liu, Jiguo Gao, Mingqin Zhu, Kangding Liu, Hong-Liang Zhang

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 294 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
294citing papers in PubMed, 7 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

294 citing papers in PubMed, 7 syntheses or guidelines pooled it, 467 citations in OpenAlex.

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  5. Nutrients · 2025
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  11. Intersections of gastrointestinal dysbiosis of the gut microbiome and aging.World journal of gastrointestinal pathophysiology · 2026
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234 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Shan LiuDepartment of Neurology, First Hospital of Jilin University, Jilin University, Xinmin Street 71, Changchun, 130021, China.
Jiguo GaoDepartment of Neurology, First Hospital of Jilin University, Jilin University, Xinmin Street 71, Changchun, 130021, China.
Mingqin ZhuDepartment of Neurology, First Hospital of Jilin University, Jilin University, Xinmin Street 71, Changchun, 130021, China.
Kangding LiuDepartment of Neurology, First Hospital of Jilin University, Jilin University, Xinmin Street 71, Changchun, 130021, China. kangdingliu@163.com.
Hong-Liang ZhangDepartment of Life Sciences, National Natural Science Foundation of China, Shuangqing Road 83, Beijing, 100085, China. drzhl@hotmail.com.ORCID http://orcid.org/0000-0001-9205-5559
Jilin University · CNNational Natural Science Foundation of China · CN

Funding

National Natural Science Foundation of China 81771299
6 · The paper itself

Abstract

Understanding how gut flora influences gut-brain communications has been the subject of significant research over the past decade. The broadening of the term "microbiota-gut-brain axis" from "gut-brain axis" underscores a bidirectional communication system between the gut and the brain. The microbiota-gut-brain axis involves metabolic, endocrine, neural, and immune pathways which are crucial for the maintenance of brain homeostasis. Alterations in the composition of gut microbiota are associated with multiple neuropsychiatric disorders. Although a causal relationship between gut dysbiosis and neural dysfunction remains elusive, emerging evidence indicates that gut dysbiosis may promote amyloid-beta aggregation, neuroinflammation, oxidative stress, and insulin resistance in the pathogenesis of Alzheimer's disease (AD). Illustration of the mechanisms underlying the regulation by gut microbiota may pave the way for developing novel therapeutic strategies for AD. In this narrative review, we provide an overview of gut microbiota and their dysregulation in the pathogenesis of AD. Novel insights into the modification of gut microbiota composition as a preventive or therapeutic approach for AD are highlighted.

Indexed as

Gastrointestinal MicrobiomeAlzheimer DiseaseAnimalsBrainDysbiosisHumansInsulin ResistanceOxidative StressAlzheimer’s diseaseGut dysbiosisGut microbiotaMicrobiota-gut-brain axis

Identifiers

PMID32829453
PMCPMC7541367
OpenAlexW3080830493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.