Evidence map›Paper›PMID 32829253›Full record

ArticleRedox biology2020

HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury.

Zong-Jie Fu, Zhi-Yu Wang, Lian Xu, Xiao-Hui Chen, Xiang-Xiao Li, Wei-Tang Liao, Hong-Kun Ma, Meng-Di Jiang, Ting-Ting Xu, Jing Xu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed, 3 pooled it
25.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

214 citing papers in PubMed, 3 syntheses or guidelines pooled it, 370 citations in OpenAlex.

  1. Interaction of HIF-1a with various cell death pathways in tumor immune microenvironment (TIME).Apoptosis : an international journal on programmed cell death · 2026
    Pooled it
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  15. Selective autophagy in kidney health and disease.Nature reviews. Nephrology · 2026
    Review
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  20. Roles of mitophagy and immune infiltration in Parkinson's disease: new perspectives from bioinformatics analysis and A53T transgenic mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article

154 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Zong-Jie FuDepartment of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai China, 200032, PR China.
Zhi-Yu WangDepartment of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China.
Lian XuDepartment of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China; Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China.
Xiao-Hui ChenDepartment of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China; Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China.
Xiang-Xiao LiDepartment of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China; Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China.
Wei-Tang LiaoResearch Center for Experimental Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China.
Hong-Kun MaDepartment of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China.
Meng-Di JiangDepartment of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China.
Ting-Ting XuDepartment of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China.
Jing XuDepartment of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China.
Yan ShenResearch Center for Experimental Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China.
Bei SongDepartment of General Practice, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China.
Ping-Jin GaoDepartment of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China; Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China.
Wei-Qing HanDepartment of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China; Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China. Electronic address: hanweiqing2000@163.com.
Wen ZhangDepartment of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China. Electronic address: zhangwen255@163.com.
Shanghai Jiao Tong University · CNRuijin Hospital · CNShanghai Institute of Hypertension · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, we hypothesized that hypoxia-inducible factor 1α (HIF-1α)-mediated mitophagy plays a protective role in ischemia/reperfusion (I/R)-induced acute kidney injury (AKI). Mitophagy was evaluated by measuring the changes of mitophagy flux, mitochondria DNA copy number, and the changes of mitophagy-related proteins including translocase of outer mitochondrial membrane 20 (TOMM20), cytochrome c oxidase IV (COX IV), microtubule-associated protein 1 light chain 3B (LC3B), and mitochondria adaptor nucleoporin p62 in HK2 cells, a human tubular cell line. Results show that HIF-1α knockout significantly attenuated hypoxia/reoxygenation (H/R)-induced mitophagy, aggravated H/R-induced apoptosis, and increased the production of reactive oxygen species (ROS). Similarly, H/R induced significantly increase in Bcl-2 19-kDa interacting protein 3 (BNIP3), a downstream regulator of HIF-1α. Notably, BNIP3 overexpression reversed the inhibitory effect of HIF-1α knockout on H/R-induced mitophagy, and prevented the enhancing effect of HIF-1α knockout on H/R-induced apoptosis and ROS production. For in vivo study, we established HIF-1α

Indexed as

MitophagyReperfusion InjuryAnimalsApoptosisHypoxia-Inducible Factor 1, alpha SubunitIschemiaKidneyMembrane ProteinsMiceMitochondriaMitochondrial ProteinsBNip3 protein, mouseHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitMembrane ProteinsMitochondrial ProteinsAcute kidney injuryBcl-2 19-kDa interacting protein 3Hypoxia-inducible factor 1αMitophagyTubular cells

Identifiers

PMID32829253
PMCPMC7452120
OpenAlexW3048150372

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.