Evidence map›Paper›PMID 32829012›Full record

ArticleFitoterapia2020

Phenethyisoquinoline alkaloids from the leaves of Androcymbium palaestinum.

Tamam El-Elimat, Maram B Alhawarri, José Rivera-Chávez, Joanna E Burdette, Austin Czarnecki, Mohammad Al-Gharaibeh, Ahmed H Al Sharie, Ahmed Alhusban, Feras Q Alali, Nicholas H Oberlies

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fitoterapia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Tamam El-ElimatDepartment of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan. Electronic address: telimat@just.edu.jo.
Maram B AlhawarriDepartment of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan.
José Rivera-ChávezDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27402, United States of America.
Joanna E BurdetteDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, United States of America.
Austin CzarneckiDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, United States of America.
Mohammad Al-GharaibehDepartment of Plant Production, Faculty of Agriculture, Jordan University of Science and Technology, Irbid 22110, Jordan.
Ahmed H Al SharieFaculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.
Ahmed AlhusbanDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan.
Feras Q AlaliFaculty of Pharmacy, Qatar University, Doha 2713, Qatar.
Nicholas H OberliesDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27402, United States of America.
Jordan University of Science and Technology · JOUniversity of Illinois Chicago · USUniversity of North Carolina at Greensboro · USQatar University · QA

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JIMMY ORJALA · 2007 to 2026
$27.2M
NCI NIH HHS P01 CA125066
6 · The paper itself

Abstract

Thirteen compounds were isolated from the methanolic extract of the leaves of Androcymbium palaestinum Baker (Colchicaceae). Of these, three were new, two were new natural products, and eight were known. The new isolated compounds were (+)-1-demethylandrocine (5), (-)-andropalaestine (8), and (+)-2-demethyl-β-lumicolchicone (10), while the new natural products were (+)-O-methylkreysigine-N-oxide (3) and (+)-O,O-dimethylautumnaline (9). Moreover, two known compounds are reported for the first time from this species, specifically (-)-colchicine (11) and (-)-3-demethyldemecolcine (13). The structures of the isolated compounds were elucidated using a series of spectroscopic and spectrometric techniques, principally HRESIMS, 1D-NMR (

Indexed as

AlkaloidsAntineoplastic Agents, PhytogenicCell Line, TumorColchicaceaeHumansIsoquinolinesJordanMolecular StructurePhytochemicalsPlant LeavesAlkaloidsAntineoplastic Agents, PhytogenicIsoquinolinesPhytochemicalsAbsolute configurationAlkaloidsAndrocymbiumCytotoxicityHuman cancer cell linesLeaves

Identifiers

PMID32829012
PMCPMC7871506
OpenAlexW3080181229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.