Evidence map›Paper›PMID 32828968›Full record

ArticlePapillomavirus research (Amsterdam, Netherlands)2020

CINtec PLUS and cobas HPV testing for triaging Canadian women referred to colposcopy with a history of low-grade squamous intraepithelial lesion: Baseline findings.

Sam Ratnam, Dan Jang, Laura Gilbert, Reza Alaghehbandan, Miranda Schell, Rob Needle, Anne Ecobichon-Morris, Peizhong Peter Wang, Mozibur Rahman, Dustin Costescu and 3 more

Erratum issuedAbstract read
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In one paragraph

Article in Papillomavirus research (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Sam RatnamMemorial University, Faculty of Medicine, St. John's, NL, Canada; McMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada; McGill University, Montreal, QC, Canada. Electronic address: sratnam@mun.ca.
Dan JangMcMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada.
Laura GilbertMemorial University, Faculty of Medicine, St. John's, NL, Canada; Eastern Health, Public Health and Microbiology Laboratory, St. John's, NL, Canada.
Reza AlaghehbandanUniversity of British Columbia, Faculty of Medicine, Vancouver, BC, Canada.
Miranda SchellMcMaster University, Hamilton Health Sciences, Hamilton, ON, Canada.
Rob NeedleMemorial University, Faculty of Medicine, St. John's, NL, Canada; Eastern Health, Public Health and Microbiology Laboratory, St. John's, NL, Canada.
Anne Ecobichon-MorrisMcMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada.
Peizhong Peter WangMemorial University, Faculty of Medicine, St. John's, NL, Canada.
Mozibur RahmanMcMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada.
Dustin CostescuMcMaster University, Hamilton Health Sciences, Hamilton, ON, Canada.
Laurie ElitMcMaster University, Hamilton Health Sciences, Hamilton, ON, Canada.
George ZahariadisMemorial University, Faculty of Medicine, St. John's, NL, Canada; Eastern Health, Public Health and Microbiology Laboratory, St. John's, NL, Canada.
Max CherneskyMcMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OBJECTIVE AND

methodsCINtec PLUS and cobas HPV tests were assessed for triaging women referred to colposcopy with a history of LSIL cytology. Both tests were performed at baseline using ThinPrep cervical specimens and biopsy confirmed cervical intraepithelial neoplasia grade 2 or worse (CIN2+) served as the clinical endpoint.

resultsIn all ages, (19-76 years, n = 600), 44.3% (266/600) tested CINtec PLUS positive vs. 55.2% (331/600) HPV positive (p = 0.000). Based on 224 having biopsies, sensitivity to detect CIN2+ (n = 54) was 81.5% (44/54) for CINtec PLUS vs. 94.4% (51/54) for HPV testing (p = 0.039); specificities were, 52.4% (89/170) vs. 44.1% (75/170), respectively (p = 0.129). In women ≥30 years (n = 386), 41.2% (159/386) tested CINtec PLUS positive vs. 50.8% (196/386) HPV positive (p = 0.008). Based on 135 having biopsies, sensitivity to detect CIN2+ (n = 24) was 95.8% (23/24) for both CINtec PLUS and HPV tests; specificities were, 55.0% (61/111) vs. 50.5% (56/111), respectively (p = 0.503).

conclusionsFor women referred to colposcopy with a history of LSIL cytology, CINtec PLUS or cobas HPV test could serve as a predictor of CIN2+ with high sensitivity, particularly in women ≥30 years. Either test can significantly reduce the number of women requiring further investigations and follow up in colposcopy clinics.

Indexed as

AdultAgedCervix UteriColposcopyDNA, ViralFemaleHumansMiddle AgedMolecular Diagnostic TechniquesOntarioPapillomaviridaePapillomavirus InfectionsProspective StudiesReagent Kits, DiagnosticSensitivity and SpecificitySquamous Intraepithelial LesionsDNA, ViralReagent Kits, DiagnosticCINtec PLUS testcobas HPV testHuman papillomavirus (HPV) triageLow-grade squamous intraepithelial lesion (LSIL) triagep16/Ki-67 dual-stain cytology

Identifiers

PMID32828968
PMCPMC7548977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.