Evidence map›Paper›PMID 32828873›Full record

Trial reportClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2021

Randomized Controlled Trial of Over-the-Scope Clip as Initial Treatment of Severe Nonvariceal Upper Gastrointestinal Bleeding.

Dennis M Jensen, Thomas Kovacs, Kevin A Ghassemi, Marc Kaneshiro, Jeffrey Gornbein

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03065465 naunknown statusnot on this map

Randomized Controlled Trial (RCT) of Standard Endoscopic Hemostasis Compared to OVESCO for Severe Non-variceal UGI Hemorrhage

TypeinterventionalSponsorCURE Digestive Diseases Research CenterRan2015 to 2025Enrolled65ConditionsUpper Gastrointestinal HemorrhageArmsOver-the-scope hemoclipping device, Standard endoscopic treatment
NCT06196710 nawithdrawnnot on this mapstarted 2025, after this paper: background citation

The Use of Over-the-scope-clips in Large Bleeding Gastro-duodenal Ulcers; a Randomized Comparison to Standard Endoscopic Hemostatic Methods

TypeinterventionalSponsorChinese University of Hong KongRan2025 to 2027Enrolled0ConditionsBleeding Peptic UlcerArmsOver-the-scope Clips, Hemo-clipping
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 78 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Comprehensive review on the current management of upper-GI bleed.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Hemostatic Use of Over-the-Scope Clips in Non-Variceal Upper Gastrointestinal Bleeding: A Narrative Review.The Korean journal of helicobacter and upper gastrointestinal research · 2025
    Review
  8. Review
  9. Article
  10. [Emerging Diagnostic Techniques and Therapies for Upper Gastrointestinal Bleeding].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Endoscopic Diagnosis and Treatment of Colonic Diverticular Bleeding.Gastrointestinal endoscopy clinics of North America · 2024
    Review
  17. Article
  18. [Gastrointestinal bleeding in old age].Zeitschrift fur Gerontologie und Geriatrie · 2024
    Article
  19. Industry perspective: the gentle bear claw at work.iGIE : innovation, investigation and insights · 2023
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dennis M JensenCURE Digestive Diseases Research Core Center, Los Angeles, California; Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California; West Los Angeles Veterans Administration Medical Center, Los Angeles, California. Electronic address: djensen@mednet.ucla.edu.
Thomas KovacsCURE Digestive Diseases Research Core Center, Los Angeles, California; Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California.
Kevin A GhassemiCURE Digestive Diseases Research Core Center, Los Angeles, California; Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California.
Marc KaneshiroCURE Digestive Diseases Research Core Center, Los Angeles, California; Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California.
Jeffrey GornbeinRonald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California; Department of Medical Statistics Core, Division of General Internal Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California.
University of California, Los Angeles · USWest Los Angeles College · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
GASTROENTEROLOGYT32DK007180 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENSEN, DENNIS MICHAEL · 1986 to 2025
$10.0M
NIDDK NIH HHS P30 DK041301NIDDK NIH HHS T32 DK007180
6 · The paper itself

Abstract

BACKGROUND AND

aimsNo prior randomized controlled trial (RCT) has reported patient outcomes of large over-the-scope clip (OTSC) compared to standard hemostasis as initial endoscopic treatment of severe NVUGIB. This was our study aim.

methodsPatients with bleeding ulcers or Dieulafoy's lesions and major stigmata of hemorrhage - SRH (active spurting bleeding, visible vessel, or clot) - or lesser SRH (oozing bleeding or flat spots - with arterial blood flow by Doppler probe) were randomized to OTSC or standard endoscopic hemostasis (with hemoclips or multipolar electrocoagulation - MPEC). Patients and their healthcare providers were blinded to treatments and made all post-randomization management decisions. Ulcer patients received high dose intravenous infusions of proton pump inhibitors (PPI) for 3 days, then 27 days of oral PPI. 30 day outcomes were prospectively recorded; data management was with SAS; and data analysis was by a statistician.

results53 patients (25 OTSC, 28 Standard) were randomized, with similar baseline risk factors. However, there were significant differences in OTSC vs. Standard groups in rates of rebleeding (4% vs. 28.6%; p = .017; relative risk 0.10, 95% confidence intervals 0.01, 0.91; number needed to treat 4); severe complications (0 % vs. 14.3%); and post-randomization units of red cell transfusions (0.04 vs. 0.68). All rebleeds occurred in patients with major SRH and none with lesser SRH.

conclusion1. OTSC significantly reduced rates of rebleeding, severe complications, and post-randomization red cell transfusions. 2. Patients with major stigmata benefited significantly from hemostasis with OTSC, but those with lesser stigmata did not. (ClinicalTrials.gov, Number: NCT03065465).

Indexed as

Hemostasis, EndoscopicGastrointestinal HemorrhageHumansProton Pump InhibitorsSurgical InstrumentsTreatment OutcomeProton Pump InhibitorsDieulafoy’s LesionHemoclipsNonvariceal UGI HemorrhageUlcer Bleeding

Identifiers

PMID32828873
PMCPMC7895857
OpenAlexW3063495048

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.