ArticleJACC. Cardiovascular imaging2021
Impact of Early Revascularization on Major Adverse Cardiovascular Events in Relation to Automatically Quantified Ischemia.
Article in JACC. Cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Systematic Review of Literature Citing the ISCHEMIA Trial.Current cardiology reports · 2024Pooled it
- Prognostic impact of epicardial fat volume, anatomical and functional imaging across the cardiovascular risk spectrum in patients with suspected coronary artery disease: a single-center retrospective cohort study.Quantitative imaging in medicine and surgery · 2026Article
- Phase entropy of gated SPECT-MPI for predicting major adverse cardiovascular events: incremental prognostic value beyond perfusion and function.Frontiers in cardiovascular medicine · 2026Article
- Review
- Reassessing Cardiovascular Risk in Patients With Peripheral Artery Disease Undergoing Myocardial Perfusion Imaging.The Canadian journal of cardiology · 2025Observational
- Real-world effectiveness of early revascularization in stable coronary artery disease with moderate or severe ischemia.American heart journal plus : cardiology research and practice · 2025Article
- AI-based identification of patients who benefit from revascularization: a multicenter study.medRxiv : the preprint server for health sciences · 2025Article
- The Relationship Between Quantitative Ischemia, Early Revascularization, and Major Adverse Cardiovascular Events: A Multicenter Study.JACC. Advances · 2025Article
- A novel algorithm developed using machine learning and a J-ACCESS database can estimate defect scores from myocardial perfusion single-photon emission tomography images.Annals of nuclear medicine · 2024Article
- Reassessing the Role of Ischemia Imaging: Insights from the ISCHEMIA Trial.Nuclear medicine and molecular imaging · 2024Review
- The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0).Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Value of Ischemia and Coronary Anatomy in Prognosis and Guiding Revascularization Among Patients With Stable Ischemic Heart Disease.Circulation. Cardiovascular imaging · 2024Article
- Prognostic value of the left ventricular ejection fraction reserve acquired by gated myocardial perfusion SPECT in patients with CAD and reduced stress LVEF.Frontiers in cardiovascular medicine · 2024Article
- Incremental prognostic value of stress phase entropy over standard PET myocardial perfusion imaging variables.European journal of nuclear medicine and molecular imaging · 2023Article
- Making fair comparisons: The potency and necessity of combining myocardial perfusion imaging and CAC scanning.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Decline in typical angina among patients referred for cardiac stress testing.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Time and event-specific deep learning for personalized risk assessment after cardiac perfusion imaging.NPJ digital medicine · 2023Article
- Improved Performance of PET Myocardial Perfusion Imaging Compared to SPECT in the Evaluation of Suspected CAD.Current cardiology reports · 2023Review
- Deep Learning Coronary Artery Calcium Scores from SPECT/CT Attenuation Maps Improve Prediction of Major Adverse Cardiac Events.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Direct Risk Assessment From Myocardial Perfusion Imaging Using Explainable Deep Learning.JACC. Cardiovascular imaging · 2023Article
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Authors and funding
22 authors at 9 institutions in 5 countries.
Funding
Abstract
objectivesUsing a contemporary, multicenter international single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) registry, this study characterized the potential major adverse cardiovascular event(s) (MACE) benefit of early revascularization based on automatic quantification of ischemia.
backgroundPrior single-center data reported an association between moderate to severe ischemia SPECT-MPI and reduced cardiac death with early revascularization.
methodsConsecutive patients from a multicenter, international registry who underwent
resultsIn total, 19,088 patients were included, with a mean follow-up of 4.7 ± 1.6 years, during which MACE occurred in 1,836 (9.6%) patients. There was a significant interaction between ischemic TPD modeled as a continuous variable and early revascularization (interaction p value: 0.012). In this model, there was a trend toward reduced MACE in patients with >5.4% ischemic TPD and a significant association with reduced MACE in patients with >10.2% ischemic TPD.
conclusionsIn this large, international, multicenter study reflecting contemporary cardiology practice, early revascularization of patients with >10.2% ischemia on SPECT-MPI, quantified automatically, was associated with reduced MACE.
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