ArticleJournal of cardiothoracic and vascular anesthesia2020
A Case Series of Devastating Intracranial Hemorrhage During Venovenous Extracorporeal Membrane Oxygenation for COVID-19.
Article in Journal of cardiothoracic and vascular anesthesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Intracranial hemorrhage in patients treated for SARS-CoV-2 with extracorporeal membrane oxygenation: A systematic review and meta-analysis.Journal of critical care · 2023Pooled it
- Characteristics of intracerebral haemorrhage associated with COVID-19: a systematic review and pooled analysis of individual patient and aggregate data.Journal of neurology · 2021Pooled it
- Longer Prehospitalization and Preintubation Periods in Intubated Non-survivors and ECMO Patients With COVID-19: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- The Use of Extracorporeal Membrane Oxygenation for COVID-19: Lessons Learned.Clinics in chest medicine · 2023Review
- Neurologic Complications of Patients With COVID-19 Requiring Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis.Critical care explorations · 2023Review
- Therapeutic Approaches to the Neurologic Manifestations of COVID-19.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Article
- Anticoagulant Use During Extracorporeal Membrane Oxygenation Using Heparin and Direct Thrombin Inhibitors in COVID-19 and ARDS Patients.The journal of extra-corporeal technology · 2022Article
- Review
- Intracranial hemorrhage in a patient with severe COVID-19 acute respiratory distress syndrome on Veno-venous extra corporeal membrane oxygenation: A case report.Annals of medicine and surgery (2012) · 2022Article
- The relationship between COVID-19 infection and intracranial hemorrhage: A systematic review.Brain hemorrhages · 2021Review
- Review of COVID-19, part 2: Musculoskeletal and neuroimaging manifestations including vascular involvement of the aorta and extremities.Clinical imaging · 2021Review
- Comprehensive Review on Neuro-COVID-19 Pathophysiology and Clinical Consequences.Neurotoxicity research · 2021Review
- Essential Topics in the Management of Venovenous Extracorporeal Membrane Oxygenation in COVID-19 Acute Respiratory Distress Syndrome.Journal of cardiothoracic and vascular anesthesia · 2021Article
- Argatroban for Anticoagulation in Patients Requiring Venovenous Extracorporeal Membrane Oxygenation in Coronavirus Disease 2019.Critical care explorations · 2021Article
- Mechanical circulatory support in coronavirus disease-2019-positive patients with severe respiratory failure.Interactive cardiovascular and thoracic surgery · 2021Article
- Intracerebral hemorrhage in COVID-19: A narrative review.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2021Review
- Intracerebral Hemorrhage in COVID-19 Patients with Pulmonary Failure: A Propensity Score-Matched Registry Study.Neurocritical care · 2021Observational
- Role of extracorporeal membrane oxygenation in critically Ill COVID-19 patients and predictors of mortality.Artificial organs · 2021Observational
- Anticoagulation Strategies and Determining the Rate of Fatal Intracerebral Hemorrhage Associated With Venovenous Extracorporeal Membrane Oxygenation in Patients With Coronavirus Disease 2019.Journal of cardiothoracic and vascular anesthesia · 2021Article
- Extracorporeal Membrane Oxygenation for COVID-19: Updated 2021 Guidelines from the Extracorporeal Life Support Organization.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2021Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAnticoagulation may be a challenge in coronavirus disease 2019 (COVID-19) extracorporeal membrane oxygenation due to endothelial injury and dysregulation of coagulation, which may increase the risk of thrombotic and bleeding complications. This report was created to describe the authors' single institutional experience, with emphasis on the high rate of intracranial hemorrhage for the first 10 patients with COVID-19 placed on venovenous extracorporeal membrane oxygenation (VV ECMO).
designCase series, retrospective analysis.
settingSingle institution.
participantsTen patients.
interventionsNone. MEASUREMENTS AND MAIN
resultsPatient characteristics, mortality, stroke rate, and length of stay data were collected in all patients. In addition, laboratory values of D-dimer and C-reactive protein and standard measurements of prothrombin and activated partial thromboplastin time were collected on all patients. Ten patients, each confirmed with COVID-19 via reverse transcription-polymerase chain reaction, were supported on VV ECMO for acute respiratory distress syndrome (ARDS) for a mean duration of 9.4 ± 7 days. Four of 10 patients had hemorrhagic strokes, 3 of which resulted in death. At 30 days after initiation of VV ECMO, a total of 7 survivors included 6 patients discharged from the hospital and 1 patient who remained in the intensive care unit.
conclusionsIn this small study of 10 patients, intracranial hemorrhage was a common complication, resulting in a high rate of death. The authors urge caution in the anticoagulation management of VV ECMO for patients with severe ARDS and COVID-19 patients. Close monitoring of all hematologic parameters is recommended during ECMO support while awaiting larger, multicenter studies to examine the best practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.