ArticleBiochemical and biophysical research communications2020
Sodium action potentials in placozoa: Insights into behavioral integration and evolution of nerveless animals.
Article in Biochemical and biophysical research communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 32 citations in OpenAlex.
- An AlphaFold guided model for the evolution of the CaMKII interactome.bioRxiv : the preprint server for biology · 2025Article
- Long-Term Culturing of Placozoans (Trichoplax and Hoilungia).Methods in molecular biology (Clifton, N.J.) · 2024Article
- Electrophysiology of Ctenophore Smooth Muscle.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Amino acids integrate behaviors in nerveless placozoans.Frontiers in neuroscience · 2023Article
- Non-Neuronal Transmitter Systems in Bacteria, Non-Nervous Eukaryotes, and Invertebrate Embryos.Biomolecules · 2022Review
- Alternative neural systems: What is a neuron? (Ctenophores, sponges and placozoans).Frontiers in cell and developmental biology · 2022Article
- Expanding of Life Strategies in Placozoa: Insights From Long-Term Culturing ofFrontiers in cell and developmental biology · 2022Article
- Evolution of glutamatergic signaling and synapses.Neuropharmacology · 2021Review
- Hidden cell diversity in Placozoa: ultrastructural insights from Hoilungia hongkongensis.Cell and tissue research · 2021Article
- Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Selective Advantages of Synapses in Evolution.Frontiers in cell and developmental biology · 2021Article
- Conserved biophysical features of the CaThe Journal of biological chemistry · 2020Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
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Abstract
Placozoa are small disc-shaped animals, representing the simplest known, possibly ancestral, organization of free-living animals. With only six morphological distinct cell types, without any recognized neurons or muscle, placozoans exhibit fast effector reactions and complex behaviors. However, little is known about electrogenic mechanisms in these animals. Here, we showed the presence of rapid action potentials in four species of placozoans (Trichoplax adhaerens [H1 haplotype], Trichoplax sp.[H2], Hoilungia hongkongensis [H13], and Hoilungia sp. [H4]). These action potentials are sodium-dependent and can be inducible. The molecular analysis suggests the presence of 5-7 different types of voltage-gated sodium channels, which showed substantial evolutionary radiation compared to many other metazoans. Such unexpected diversity of sodium channels in early-branched metazoan lineages reflect both duplication events and parallel evolution of unique behavioral integration in these nerveless animals.
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