ArticleBiological psychiatry2021
Microstructure of the Dorsal Anterior Cingulum Bundle in Very Preterm Neonates Predicts the Preterm Behavioral Phenotype at 5 Years of Age.
Article in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Internalizing and Externalizing Symptoms in Children and Adolescents Born Preterm or Low Birth Weight: A Meta-Analysis.Journal of youth and adolescence · 2025Pooled it
- Maternal depression with and without a history of childhood maltreatment and newborn white matter microstructure.Psychological medicine · 2026Article
- Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Cognition, internalizing symptoms and neonatal cingulate-amygdala interaction in children born very low birth weight.Frontiers in pediatrics · 2026Article
- Social Determinants of Health and Early Brain Development.Pediatric clinics of North America · 2025Review
- Associations Between Preterm Birth, Inhibitory Control-Implicated Brain Regions and Tracts, and Inhibitory Control Task Performance in Children: Consideration of Socioeconomic Context.Child psychiatry and human development · 2025Article
- Adverse Childhood Experiences and Socioemotional Outcomes of Children Born Very Preterm.The Journal of pediatrics · 2025Article
- Associations of behavioral problems with white matter circuits connecting to the frontal lobes in school-aged children born at term and preterm.Neuroimage. Reports · 2024Article
- Prenatal exposure to maternal disadvantage-related inflammatory biomarkers: associations with neonatal white matter microstructure.Translational psychiatry · 2024Article
- Subtle microstructural alterations in white matter tracts involved in socio-emotional processing after very preterm birth.NeuroImage. Clinical · 2024Article
- The First "Hit" to the Endocannabinoid System? Associations Between Prenatal Cannabis Exposure and Frontolimbic White Matter Pathways in Children.Biological psychiatry global open science · 2024Article
- Person-centred Approaches to Psychopathology in the ABCD Study: Phenotypes and Neurocognitive Correlates.Research on child and adolescent psychopathology · 2023Article
- Early biomarkers of neurodevelopmental disorders in preterm infants: protocol for a longitudinal cohort study.BMJ open · 2023Article
- Social disadvantage during pregnancy: effects on gestational age and birthweight.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Article
- Prenatal exposure to maternal social disadvantage and psychosocial stress and neonatal white matter connectivity at birth.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Maternal depressive symptoms, neonatal white matter, and toddler social-emotional development.Translational psychiatry · 2022Article
- The Structural Connectome and Internalizing and Externalizing Symptoms at 7 and 13 Years in Individuals Born Very Preterm and Full Term.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Neurodevelopmental disorders: 2021 update.Free neuropathology · 2021Article
- Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe cingulum bundle (CB), specifically the dorsal anterior portion of the CB, plays an important role in psychiatric illnesses; however, its role during early development is unclear. This study investigated whether neonatal white matter microstructure in the CB and its subregions is associated with subsequent preterm behavioral phenotype symptoms (internalizing, inattention, and social deficits) in very preterm (VPT) children.
methodsDiffusion magnetic resonance imaging data were obtained on a 3T scanner in 138 sleeping nonsedated neonates: 55 full-term neonates (gestational age ≥ 36 weeks) and 83 VPT neonates (gestational age < 30 weeks). The CB was tracked using probabilistic tractography and split into anterior and posterior portions. When children were 5 years of age, parents (n = 80) and teachers (n = 63) of VPT children completed questionnaires of preterm behavioral phenotype symptoms. Linear regression models were used to relate measures of neonatal CB microstructure and childhood preterm behavioral phenotype symptoms (n = 56 parent report, n = 45 teacher report).
resultsMean diffusivity in the anterior and posterior CB was increased in VPT neonates compared with full-term neonates. Increased fractional anisotropy and decreased mean diffusivity in the right anterior CB, but not in the posterior CB, were related to increased preterm behavioral phenotype symptoms in VPT children as reported by parents and teachers.
conclusionsAberrations in the anterior portion of the right CB may underlie the early development of the preterm behavioral phenotype. This finding provides the foundation for future mechanistic and therapeutic investigations into the role of the anterior cingulum in the development of psychopathology in VPT infants.
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