Evidence map›Paper›PMID 32828189›Full record

ReviewLancet (London, England)2020

Sex and gender: modifiers of health, disease, and medicine.

Franck Mauvais-Jarvis, Noel Bairey Merz, Peter J Barnes, Roberta D Brinton, Juan-Jesus Carrero, Dawn L DeMeo, Geert J De Vries, C Neill Epperson, Ramaswamy Govindan, Sabra L Klein and 8 more

Erratum issued Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lancet (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04865029 (Acute Estradiol and Progesterone Therapy in Hospitalized Adults to Reduce Coronavirus Disease), which is not on this map. Cited by 1,051 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,051citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04865029 phase2terminatednot on this mapstarted 2021, after this paper: background citation

Acute Estradiol and Progesterone Therapy in Hospitalized Adults to Reduce Coronavirus Disease (COVID-19) Severity: A Randomized Control Trial

TypeinterventionalSponsorTulane UniversityRan2021 to 2022Enrolled10ConditionsCovid19ArmsPlacebo injection and placebo pill, Estradiol Cypionate 5 mg/ml, Progesterone 200 mg Oral Capsule
3 · Its place in the literature

Who cites it

1,051 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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991 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Franck Mauvais-JarvisDiabetes Discovery & Sex-Based Medicine Laboratory, Section of Endocrinology, John W Deming Department of Medicine, Tulane University School of Medicine and Southeast Louisiana Veterans Health Care System Medical Center, New Orleans, LA, USA. Electronic address: fmauvais@tulane.edu.
Noel Bairey MerzBarbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.
Peter J BarnesNational Heart & Lung Institute, Imperial College London, London, UK.
Roberta D BrintonDepartment of Pharmacology and Department of Neurology, College of Medicine, Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, USA.
Juan-Jesus CarreroDepartment of Medical Epidemiology and Biostatistics and Center for Gender Medicine, Karolinska Institutet, Stockholm, Sweden.
Dawn L DeMeoChanning Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Geert J De VriesNeuroscience Institute and Department of Biology, Georgia State University, Atlanta, GA, USA.
C Neill EppersonDepartment of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.
Ramaswamy GovindanDivision of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Sabra L KleinW Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Amedeo LonardoDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Ospedale Civile di Baggiovara, Modena, Italy.
Pauline M MakiDepartment of Psychiatry, Department of Psychology, and Department of Obstetrics & Gynecology, University of Illinois at Chicago, Chicago, IL, USA.
Louise D McCulloughDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Vera Regitz-ZagrosekBerlin Institute of Gender Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany; Department of Cardiology, University Hospital Zürich, University of Zürich, Switzerland.
Judith G RegensteinerCenter for Women's Health Research, Divisions of General Internal Medicine and Cardiology, University of Colorado School of Medicine, Aurora, CO, USA.
Joshua B RubinDepartment of Medicine, Department of Paediatrics, and Department of Neuroscience, Washington University School of Medicine St Louis, MO, USA.
Kathryn SandbergCenter for the Study of Sex Differences in Health, Aging and Disease, Georgetown University, Washington, DC, USA.
Ayako SuzukiDivision of Gastroenterology, Duke University Medical Center Durham, NC, USA; Durham VA Medical Center, Durham, NC, USA.

Funding

Timing of Menopausal Hormone Therapy across Perimenopause to Menopause Transition: Neuroimmune System in BrainP01AG026572 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROBERTA EILEEN BRINTON · 2006 to 2026
$53.7M
Respiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, MARY E · 2013 to 2025
$24.9M
Systems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6M
Systems Biology, Bioinformatics, and BiostatisticsP01HL105339 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2011 to 2015
$12.2M
Sex differences in the impact of frailty on vaccine-induced immune responses in community-dwelling older adultsU54AG062333 · NIA · JOHNS HOPKINS UNIVERSITY · PI KLEIN, SABRA L. · 2018 to 2022
$8.9M
UCHSC: Building Interdisciplinary Research Careers in Women's HealthK12HD057022 · NICHD · UNIVERSITY OF COLORADO DENVER · PI REGENSTEINER, JUDITH G., SANTORO, NANETTE F. · 2007 to 2023
$8.5M
Targeting the estrogen receptor-α to protect functional β-cell mass in womenR01DK074970 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Franck Mauvais-Jarvis · 2007 to 2026
$6.0M
Sex Differences in the Molecular Determinants of Alzheimer's Disease Risk: Prodromal EndophenotypeR01AG057931 · NIA · UNIVERSITY OF ARIZONA · PI BRINTON, ROBERTA EILEEN, CHANG, RUI · 2018 to 2022
$6.0M
Metabolic Networks and Pathways Predictive of Sex Differences in AD Risk and Responsiveness to TreatmentRF1AG059093 · NIA · DUKE UNIVERSITY · PI BRINTON, ROBERTA EILEEN, CHANG, RUI · 2018 to 2018
$5.9M
Pyschosocial Stress and the Response to StrokeR37NS096493 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCCULLOUGH, LOUISE D. · 2016 to 2022
$5.2M
Aging and Estrogenic Control of the Bioenergetic System in BrainR37AG053589 · NIA · UNIVERSITY OF ARIZONA · PI ROBERTA EILEEN BRINTON · 2017 to 2026
$4.2M
MOLECULAR BASIS FOR THE IMPACT OF SEX ON BRAIN TUMORIGENESISR01CA174737 · NCI · WASHINGTON UNIVERSITY · PI RUBIN, JOSHUA B · 2014 to 2024
$3.5M
BLRD VA I01 BX003725CSRD VA I01 CX001532NCI NIH HHS R01 CA174737NHLBI NIH HHS P01 HL105339NHLBI NIH HHS P01 HL114501NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL119380NIA NIH HHS P01 AG026572NIA NIH HHS R01 AG057931NIA NIH HHS R21 AG060730NIA NIH HHS R37 AG053589NIA NIH HHS RF1 AG059093NIA NIH HHS U54 AG062333NICHD NIH HHS K12 HD057022NIDDK NIH HHS R01 DK074970NIDDK NIH HHS R01 DK107444NINDS NIH HHS R37 NS096493
6 · The paper itself

Abstract

Clinicians can encounter sex and gender disparities in diagnostic and therapeutic responses. These disparities are noted in epidemiology, pathophysiology, clinical manifestations, disease progression, and response to treatment. This Review discusses the fundamental influences of sex and gender as modifiers of the major causes of death and morbidity. We articulate how the genetic, epigenetic, and hormonal influences of biological sex influence physiology and disease, and how the social constructs of gender affect the behaviour of the community, clinicians, and patients in the health-care system and interact with pathobiology. We aim to guide clinicians and researchers to consider sex and gender in their approach to diagnosis, prevention, and treatment of diseases as a necessary and fundamental step towards precision medicine, which will benefit men's and women's health.

Indexed as

Cause of DeathHealth StatusSex DistributionAcute DiseaseBetacoronavirusChronic DiseaseCoronavirus InfectionsCOVID-19FemaleHumansMalePandemicsPneumonia, ViralPrecision MedicineSARS-CoV-2Sex Characteristics

Identifiers

PMID32828189
PMCPMC7440877

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.