Evidence map›Paper›PMID 32827669›Full record

ReviewBiotechnology advances2021

Recent developments in the use of peroxygenases - Exploring their high potential in selective oxyfunctionalisations.

Markus Hobisch, Dirk Holtmann, Patricia Gomez de Santos, Miguel Alcalde, Frank Hollmann, Selin Kara

Open access · hybridAbstract readReview
In one paragraph

Review in Biotechnology advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 181 citations in OpenAlex.

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  15. Rapid screening system to identify unspecific peroxygenase activity.Clinical hemorheology and microcirculation · 2025
    Article
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  19. Understanding the stability of a plastic-degrading Rieske iron oxidoreductase system.Protein science : a publication of the Protein Society · 2024
    Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Markus HobischDepartment of Engineering, Biocatalysis and Bioprocessing Group, Aarhus University, Gustav Wieds Vej 10, Aarhus C 8000, Denmark.
Dirk HoltmannInstitute of Bioprocess Engineering and Pharmaceutical Technology, University of Applied Sciences Mittelhessen, Wiesenstr. 14, Gießen 35390, Germany.
Patricia Gomez de SantosDepartment of Biocatalysis, Institute of Catalysis, CSIC, C/Marie Curie 2, Madrid 28049, Spain.
Miguel AlcaldeDepartment of Biocatalysis, Institute of Catalysis, CSIC, C/Marie Curie 2, Madrid 28049, Spain; EvoEnzyme S.L, C/ Marie Curie 2, Madrid 28049, Spain.
Frank HollmannDepartment of Biotechnology, Biocatalysis Group, Delft University of Technology, Van der Maasweg 9, Delft 2629 HZ, The Netherlands.
Selin KaraDepartment of Engineering, Biocatalysis and Bioprocessing Group, Aarhus University, Gustav Wieds Vej 10, Aarhus C 8000, Denmark. Electronic address: selin.kara@eng.au.dk.
Aarhus University · DKInstituto de Catálisis y Petroleoquímica · ESDelft University of Technology · NLTechnische Hochschule Mittelhessen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peroxygenases are an emerging new class of enzymes allowing selective oxyfunctionalisation reactions in a cofactor-independent way different from well-known P450 monooxygenases. Herein, we focused on recent developments from organic synthesis, molecular biotechnology and reaction engineering viewpoints that are devoted to bring these enzymes in industrial applications. This covers natural diversity from different sources, protein engineering strategies for expression, substrate scope, activity and selectivity, stabilisation of enzymes via immobilisation, and the use of peroxygenases in low water media. We believe that peroxygenases have much to offer for selective oxyfunctionalisations and we have much to study to explore the full potential of these versatile biocatalysts in organic synthesis.

Indexed as

Mixed Function OxygenasesProtein EngineeringMixed Function OxygenasesperoxygenaseFungal enzymeOxidation chemistryOxyfunctionalisationOxygenasePeroxygenase

Identifiers

PMID32827669
PMCPMC8444091
OpenAlexW3050216513

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.