ArticleReproductive toxicology (Elmsford, N.Y.)2020
The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity.
Article in Reproductive toxicology (Elmsford, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Comparison of transcriptomic points of departure with apical endpoints in developing zebrafish exposed to PFOS, PFOA, or PFHxS.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Leveraging Zebrafish Embryo Phenotypic Observations to Advance Data-Driven Analyses in Toxicology.Environmental science & technology · 2025Article
- Aryl phosphate ester-induced pericardial edema in zebrafish embryos is influenced by the ionic composition of exposure media.Aquatic toxicology (Amsterdam, Netherlands) · 2024Article
- Developmental Toxicity Assessment Using Zebrafish-Based High-Throughput Screening.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Advances in PAH mixture toxicology enabled by zebrafish.Current opinion in toxicology · 2023Article
- The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes.Scientific data · 2023Article
- A Comparative Multi-System Approach to Characterizing Bioactivity of Commonly Occurring Chemicals.International journal of environmental research and public health · 2022Article
- Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity.iScience · 2022Article
- Pilot-scale expanded assessment of inorganic and organic tapwater exposures and predicted effects in Puerto Rico, USA.The Science of the total environment · 2021Article
- Gene co-expression network analysis in zebrafish reveals chemical class specific modules.BMC genomics · 2021Article
- Review
- Phenotypically Anchored mRNA and miRNA Expression Profiling in Zebrafish Reveals Flame Retardant Chemical Toxicity Networks.Frontiers in cell and developmental biology · 2021Article
- Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-well plate format used in zebrafish larvae toxicology studies.Journal of pharmacological and toxicological methodsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Flame retardant chemicals (FRCs) commonly added to many consumer products present a human exposure burden associated with adverse health effects. Under pressure from consumers, FRC manufacturers have adopted some purportedly safer replacements for first-generation brominated diphenyl ethers (BDEs). In contrast, second and third-generation organophosphates and other alternative chemistries have limited bioactivity data available to estimate their hazard potential. In order to evaluate the toxicity of existing and potential replacement FRCs, we need efficient screening methods. We built a 61-FRC library in which we systemically assessed developmental toxicity and potential neurotoxicity effects in the embryonic zebrafish model. Data were compared to publicly available data generated in a battery of cell-based in vitro assays from ToxCast, Tox21, and other alternative models. Of the 61 FRCs, 19 of 45 that were tested in the ToxCast assays were bioactive in our zebrafish model. The zebrafish assays detected bioactivity for 10 of the 12 previously classified developmental neurotoxic FRCs. Developmental zebrafish were sufficiently sensitive at detecting FRC structure-bioactivity impacts that we were able to build a classification model using 13 physicochemical properties and 3 embryonic zebrafish assays that achieved a balanced accuracy of 91.7%. This work illustrates the power of a multi-dimensional in vivo platform to expand our ability to predict the hazard potential of new compounds based on structural relatedness, ultimately leading to reliable toxicity predictions based on chemical structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.