Evidence map›Paper›PMID 32827354›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021

Education differentially contributes to cognitive reserve across racial/ethnic groups.

Justina F Avila, Miguel Arce Rentería, Richard N Jones, Jet M J Vonk, Indira Turney, Ketlyne Sol, Dominika Seblova, Franchesca Arias, Tanisha Hill-Jarrett, Shellie-Anne Levy and 17 more

Open access · greenAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Superficial white matter and gray matter jointly support cognition among older adults in India.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Cognitive reserve against vascular contributions to cognitive impairment and dementia: A scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  12. Brain and cognitive correlates of social status across race/ethnicity and sex/gender.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  13. Article
  14. Article
  15. Measurement equivalence of the UDS version 2.0 and 3.0 neuropsychological batteries.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
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  17. Observational
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 16 institutions in 2 countries.

Justina F AvilaDepartment of Psychology, University of New Mexico, Albuquerque, New Mexico, USA.
Miguel Arce RenteríaTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Richard N JonesDepartment of Neurology, Warren Alpert Medical School, Brown University, Butler Hospital, Providence, Rhode Island, USA.
Jet M J VonkTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Indira TurneyTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Ketlyne SolDepartment of Psychology, University of Michigan, Michigan, Ann Arbor, USA.
Dominika SeblovaTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Franchesca AriasAging Brain Center, Hebrew Senior Life, Harvard Medical School Affiliate, Boston, Massachusetts, USA.
Tanisha Hill-JarrettDepartment of Neurosurgery, University of South Florida, Florida, Tampa, USA.
Shellie-Anne LevyDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
Oanh MeyerDepartment of Neurology, University of California Davis School of Medicine, Sacramento, California, USA.
Annie M RacineBiogen Inc, Cambridge, Massachusetts, USA.
Sarah E TomGertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Rebecca J MelroseVA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Kacie DetersDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.
Luis D MedinaDepartment of Psychology, University of Houston, Houston, Texas, USA.
Carmen I CarriónDepartment of Neurology, School of Medicine, Yale University, New Haven, Connecticut, USA.
Mirella Díaz-SantosDepartment of Psychiatry & Biobehavioral Sciences, University of California Los, Angeles, California, USA.
DeAnnah R ByrdInstitute of Gerontology, Wayne State University, Detroit, Michigan, USA.
Anthony ChesebroTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Juliet ColonTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Kay C IgweTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Benjamin MaasTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Adam M BrickmanTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Nicole SchupfTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Richard MayeuxTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Jennifer J ManlyTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Columbia University · USBiogen (United States) · USButler Hospital · USHebrew SeniorLife · USNeurobehavioral Systems · USStanford University · USUniversity of California, Davis · USUniversity of Florida Health · USUniversity of Houston · USUniversity of Michigan–Ann Arbor · USUniversity of New Mexico · USUniversity of South Florida · USUtrecht University · NLVA Greater Los Angeles Healthcare System · USWayne State University · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LUCHSINGER, JOSE ALEJANDRO · 1989 to 2008
$21.7M
Epidemiological and Genetic Investigations of Blood-Based Biomarkers for Alzheimer's Disease in the Multiethnic, Washington Heights, Inwood, Columbia Aging Project (WHICAP)R01AG072474 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, MANLY, JENNIFER JAIE · 2021 to 2025
$13.3M
Epidemiological Integration of Genetic Variants and Metabolomics Profiles in Washington Heights Columbia Aging ProjectRF1AG066107 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, MILLER, GARY W · 2020 to 2022
$11.4M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
Resilience Mechanisms Underlying Racial/Ethnic Disparities in Alzheimer’s DiseaseR01AG054520 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, ZAHODNE, LAURA B · 2017 to 2021
$5.8M
Stanford Medicine Center for Longevity and Healthy Aging Research Education CoreP30AG059307 · NIA · STANFORD UNIVERSITY · PI ZOU, JAMES · 2018 to 2025
$4.9M
Conference on Advanced Psychometric Methods in Cognitive Aging ResearchR13AG030995 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MUNGAS, DAN M. · 2008 to 2022
$620k
NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR001873NIA NIH HHS P01 AG007232NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG054520NIA NIH HHS R01 AG072474NIA NIH HHS R13 AG030995NIA NIH HHS RF1 AG054023NIA NIH HHS RF1 AG066107
6 · The paper itself

Abstract

introductionWe examined whether educational attainment differentially contributes to cognitive reserve (CR) across race/ethnicity.

methodsA total of 1553 non-Hispanic Whites (Whites), non-Hispanic Blacks (Blacks), and Hispanics in the Washington Heights-Inwood Columbia Aging Project (WHICAP) completed structural magnetic resonance imaging. Mixture growth curve modeling was used to examine whether the effect of brain integrity indicators (hippocampal volume, cortical thickness, and white matter hyperintensity [WMH] volumes) on memory and language trajectories was modified by education across racial/ethnic groups.

resultsHigher educational attainment attenuated the negative impact of WMH burden on memory (β = -0.03; 99% CI: -0.071, -0.002) and language decline (β = -0.024; 99% CI:- 0.044, -0.004), as well as the impact of cortical thinning on level of language performance for Whites, but not for Blacks or Hispanics. DISCUSSION: Educational attainment does not contribute to CR similarly across racial/ethnic groups.

Indexed as

Cognitive ReserveEducational StatusEthnicityRacial GroupsAgedAged, 80 and overAgingBlack or African AmericanBrainCognitive AgingFemaleHispanic or LatinoHumansLanguageMagnetic Resonance ImagingMalecognitive agingcognitive reserveeducationracial/ethnic differences

Identifiers

PMID32827354
PMCPMC8376080
OpenAlexW3081468685

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.