Evidence map›Paper›PMID 32827234›Full record

ArticleJournal of clinical laboratory analysis2020

Short-term biological variation and Reference change values of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine.

Ruiping Zhang, Songlin Yu, Danchen Wang, Yicong Yin, Jialei Yu, Yongtong Cao, Ling Qiu

Abstract read
In one paragraph

Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Diurnal and daily fluctuations in levels of the urinary oxidative stress marker 8-hydroxyguanosine in spot urine samples.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruiping ZhangDepartment of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
Songlin YuDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Danchen WangDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.ORCID https://orcid.org/0000-0003-2688-3203
Yicong YinDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Jialei YuDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Yongtong CaoDepartment of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
Ling QiuDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-0734-8144

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe DNA and RNA oxidative damage products urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-odGsn) and 8-oxo-7,8-dihydroguanosine (8-oGsn) have potential use in clinical practice. However, biological variation (BV) and reference change values (RCVs) have not been established. The aim of this study was to establish the short-term between-subject BV(CV

methodsFirst-morning midstream urine specimens were collected from 20 apparently healthy subjects(ten males and ten females) on five consecutive days. 8-odGsn and 8-oGsn were measured using LC-MS/MS, while urine creatinine (U-Cr) was also measured to correct their results. A two-level nested ANOVA was used to estimate the CV

conclusionBV and RCVs were firstly established for 8-oxo-dGsn and 8-oGsn, and can be used in clinical practice.

Indexed as

8-Hydroxy-2'-DeoxyguanosineAdultBiomarkersFemaleGuanosineHumansMaleMiddle AgedOxidative StressReference ValuesYoung Adult8-Hydroxy-2'-Deoxyguanosine8-hydroxyguanosineBiomarkersGuanosine8-oxo-7,8-dihydro-2'-deoxyguanosine8-oxo-7,8-dihydroguanosinebiological variationoxidative damage biomarkersreference change values

Identifiers

PMID32827234
PMCPMC7755802

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.