Evidence map›Paper›PMID 32826992›Full record

ReviewNature reviews. Microbiology2021

The population genetics of pathogenic Escherichia coli.

Erick Denamur, Olivier Clermont, Stéphane Bonacorsi, David Gordon

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 359 papers.

0numbers the graph read from it
0cells of the map it votes in
359citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

359 citing papers in PubMed.

  1. Virulence · 2026
    Review
  2. Article
  3. Standardization and evaluation of artificial intelligence-driven Fourier-transform infrared bio-typing for the discrimination of Escherichia coli and Shigella spp. on genus, species and serogroup level.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Detection of an ExPEC-likeBiotech (Basel (Switzerland)) · 2026
    Article
  11. Article
  12. Molecular characterization of extended-spectrum β-lactamases-producing Escherichia coli isolated from patients with bacteremia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  13. Article
  14. Article
  15. Genomic Characterization, Antimicrobial Resistance Profiles, andAnimals : an open access journal from MDPI · 2026
    Article
  16. Article
  17. Multidrug resistance of bacterial pathogens in canine pyometra.The Journal of small animal practice · 2026
    Article
  18. Article
  19. Review
  20. Article

299 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Erick DenamurUniversité de Paris, IAME, UMR1137, INSERM, Paris, France. erick.denamur@inserm.fr.ORCID http://orcid.org/0000-0002-7860-1717
Olivier ClermontUniversité de Paris, IAME, UMR1137, INSERM, Paris, France.
Stéphane BonacorsiUniversité de Paris, IAME, UMR1137, INSERM, Paris, France.
David GordonEcology and Evolution, Research School of Biology, The Australian National University, Acton, ACT, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Escherichia coli is a commensal of the vertebrate gut that is increasingly involved in various intestinal and extra-intestinal infections as an opportunistic pathogen. Numerous pathotypes that represent groups of strains with specific pathogenic characteristics have been described based on heterogeneous and complex criteria. The democratization of whole-genome sequencing has led to an accumulation of genomic data that render possible a population phylogenomic approach to the emergence of virulence. Few lineages are responsible for the pathologies compared with the diversity of commensal strains. These lineages emerged multiple times during E. coli evolution, mainly by acquiring virulence genes located on mobile elements, but in a specific chromosomal phylogenetic background. This repeated emergence of stable and cosmopolitan lineages argues for an optimization of strain fitness through epistatic interactions between the virulence determinants and the remaining genome.

Indexed as

Genome, BacterialGenomicsEscherichia coliEscherichia coli InfectionsEvolution, MolecularHumansPhenotypePhylogenyVirulenceVirulence FactorsVirulence Factors

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.