SynthesisCommunications biology2020
Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis.
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In one paragraph
Synthesis in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Genome-wide association for sarcoidosis identifies novel risk loci and genetic heritability in African and European ancestries: a meta-analysis from the Finngen, Million Veteran Program, UK Biobank, and Biobank Japan datasets.Orphanet journal of rare diseases · 2025Pooled it
- Ectopic co-expression of canonical and LINE1 and THE1A-exonizing IL23R transcripts in sarcoid myopathy.Journal of human genetics · 2026Article
- Sex-Specific Transcriptomic Profiles in Psoriatic Lesions: A Large-Scale Integrative Study.International journal of molecular sciences · 2026Article
- Lymphocyte signal transduction defects in cutaneous sarcoidosis and implications for treatment.Frontiers in immunology · 2026Review
- [Clinical features and prognosis of sarcoidosis with ocular lesions as the initial manifestation].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- Sarcoidosis in the Genomic Era: From Genetic Drivers to Tailored Therapies.Current allergy and asthma reports · 2025Review
- Prevalence and clinical characteristics of ocular sarcoidosis among non-infectious uveitis in a Chinese tertiary ophthalmic center: a retrospective observational study.BMC ophthalmology · 2025Observational
- The Genetic Background of Ankylosing Spondylitis Reveals a Distinct Overlap with Autoimmune Diseases: A Systematic Review.Journal of clinical medicine · 2025Review
- GWAS identifies genetic loci, lifestyle factors and circulating biomarkers that are risk factors for sarcoidosis.Nature communications · 2025Article
- Immune mechanisms of granuloma formation in sarcoidosis and tuberculosis.The Journal of clinical investigation · 2024Review
- HLA class II variants defined by next generation sequencing are associated with sarcoidosis in Korean patients.Scientific reports · 2022Article
- Epigenetics and sarcoidosis.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Pathogenesis of Non-Infectious Uveitis Elucidated by Recent Genetic Findings.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors at 20 institutions in 4 countries.
Akira MeguroDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Mami IshiharaDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Martin PetrekDepartment of Pathological Physiology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska Str., 77515, Olomouc, Czech Republic.ORCID http://orcid.org/0000-0002-4517-7825
Ken YamamotoDepartment of Medical Biochemistry, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.ORCID http://orcid.org/0000-0002-1531-9685
Masaki TakeuchiDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Frantisek MrazekDepartment of Immunology, Faculty of Medicine and Dentistry, Palacky University, I.P.Pavlova Str. 6, 77520, Olomouc, Czech Republic.
Vitezslav KolekDepartment of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacky University, I. P. Pavlova Str. 6, 77900, Olomouc, Czech Republic.
Alzbeta BenickaDepartment of Pathological Physiology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska Str., 77515, Olomouc, Czech Republic.
Takahiro YamaneDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Etsuko ShibuyaDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Atsushi YoshinoDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Akiko IsomotoDivision of Genome Analysis, Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 812-8582, Japan.
Masao OtaDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Keisuke YatsuDepartment of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Noriharu ShijuboDepartment of Respiratory Medicine, Japan Railway Sapporo Hospital, Higashi-1, Kita-3, Chuo-ku, Sapporo, 060-0033, Japan.
Sonoko NagaiKyoto Central Clinic/Clinical Research Center, 56-58 Masuyacho Sanjo-Takakura, Nakagyo-ku, Kyoto, 604-8111, Japan.
Etsuro YamaguchiDivision of Respiratory Medicine and Allergology, Aichi Medical University, 21 Karimata, Yazako, Nagakute-cho, Aichi-gun, Aichi, 480-1195, Japan.
Tetsuo YamaguchiDepartment of Respiratory Medicine, Japan Railway Tokyo General Hospital, 2-1-3 Yoyogi, Shibuya-ku, Tokyo, 151-0053, Japan.
Kenichi NambaDepartment of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
Toshikatsu KaburakiDepartment of Ophthalmology, University of Tokyo School of Medicine, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Hiroshi TakaseDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.ORCID http://orcid.org/0000-0001-8327-803X
Shin-Ichiro MorimotoDivision of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, 470-1192, Japan.
Junko HoriDepartment of Ophthalmology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.ORCID http://orcid.org/0000-0002-4248-5742
Keiko KonoDepartment of Ophthalmology, Kono Medical Clinic, 3-30-28 Soshigaya, Setagaya-ku, Tokyo, 157-0072, Japan.
Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Takafumi SudaSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan.
Soichiro IkushimaDepartment of Respiratory Medicine, Japanese Red Cross Medical Centre, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8953, Japan.
Yasutaka AndoDepartment of Ophthalmology, Kitasato Institute Hospital, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8642, Japan.
Shinobu TakenakaDepartment of Respiratory Diseases, Kumamoto City Hospital, 1-1-60 Kotoh, Kumamoto, Kumamoto, 862-8505, Japan.
Masaru TakeuchiDepartment of Ophthalmology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
Takenosuke YuasaYuasa Eye Clinic, 3-1-1 Nishimoto-cho, Nishi-ku, Osaka, 550-0005, Japan.
Katsunori SugisakiDepartment of Internal Medicine, National Hospital Organization Nishibeppu National Hospital, 4548 Oaza-Tsurumi, Beppu, Oita, 874-0840, Japan.
Nobuyuki OhguroDepartment of Ophthalmology, Japan Community Health care Organization Osaka Hospital, 4-2-78 Fukushima, Fukushima-ku, Osaka, 553-0003, Japan.
Miki HiraokaDepartment of Ophthalmology, School of Medicine, Sapporo Medical University, S1 W16 Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.
Nobuyoshi KitaichiDepartment of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
Yukihiko SugiyamaDivision of Pulmonary Medicine, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
Nobuyuki HoritaInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, 10 CRC East/B2-5235, Bethesda, MD, 20892-1849, USA.
Yuri AsukataDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Tatsukata KawagoeDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Ikuko KimuraDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Mizuho IshidoDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Hidetoshi InokoINSERM Franco-Japanese "Laboratoire International Associé" (LIA) Nextgen HLA Laboratory, Strasbourg, France.
Manabu MochizukiDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Shigeaki OhnoDepartment of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
Seiamak BahramINSERM Franco-Japanese "Laboratoire International Associé" (LIA) Nextgen HLA Laboratory, Strasbourg, France.ORCID http://orcid.org/0000-0002-6928-9952
Elaine F RemmersInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, 10 CRC East/B2-5235, Bethesda, MD, 20892-1849, USA.
Daniel L KastnerInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, 10 CRC East/B2-5235, Bethesda, MD, 20892-1849, USA.
Nobuhisa MizukiDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan. mizunobu@yokohama-cu.ac.jp.ORCID http://orcid.org/0000-0003-3738-8777
Yokohama City University · JPNational Institutes of Health · USPalacký University Olomouc · CZHealth Sciences University of Hokkaido · JPTokyo Medical and Dental University · JPAichi Medical University · JPFujita Health University Hospital · JPHamamatsu University School of Medicine · JPHokkaido University · JPInserm · FRJapanese Red Cross Medical Center · JPJichi Medical University · JPJR Tokyo General Hospital · JPKeio University Hospital · JPKeiyukai Sapporo Hospital · JPKumamoto City Hospital · JPKurume University · JPKyushu University · JPNational Hospital Organization · JPNippon Medical School · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcoidosis is a genetically complex systemic inflammatory disease that affects multiple organs. We present a GWAS of a Japanese cohort (700 sarcoidosis cases and 886 controls) with replication in independent samples from Japan (931 cases and 1,042 controls) and the Czech Republic (265 cases and 264 controls). We identified three loci outside the HLA complex, CCL24, STYXL1-SRRM3, and C1orf141-IL23R, which showed genome-wide significant associations (P < 5.0 × 10
Indexed as
Genetic Predisposition to DiseaseAllelesChemokine CCL24Cytochrome P-450 Enzyme SystemFemaleGenetic Association StudiesGenome-Wide Association StudyGenotypeHumansJapanMaleOdds RatioPolymorphism, Single NucleotideQuantitative Trait LociReceptors, InterleukinSarcoidosisCCL24 protein, humanChemokine CCL24Cytochrome P-450 Enzyme SystemIL23R protein, humanPOR protein, humanReceptors, Interleukin
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