Evidence map›Paper›PMID 32826966›Full record

ReviewNature reviews. Gastroenterology & hepatology2020

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics.

Kelly S Swanson, Glenn R Gibson, Robert Hutkins, Raylene A Reimer, Gregor Reid, Kristin Verbeke, Karen P Scott, Hannah D Holscher, Meghan B Azad, Nathalie M Delzenne and 1 more

3 registry-linked trialsOpen access · hybridAbstract readConsensus Development Conference, NIHReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 693 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
693citing papers in PubMed, 15 pooled it
87.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04534036 nacompletednot on this map

A 12-week Randomized, Double-Blind Controlled Trial to Evaluate the Tolerability and Gastrointestinal Response of a Novel, Multi-Strain Synbiotic (PDS-08™) in Children Ages 3-17

TypeinterventionalSponsorSeed HealthRan2020 to 2022Enrolled64ConditionsConstipation, Signs and Symptoms, Digestive Signs and Symptoms, Infrequent or Difficult EvacuationArmsPDS-08, Placebo
NCT06030999 nacompletednot on this mapstarted 2023, after this paper: background citation

Three Arms, Randomized, Double-blind Controlled Trial Of Prevention And Treatment On Obesity And Weight Management By Oral Supplementation Of Probiotics And Prebiotics

TypeinterventionalSponsorShenzhen Precision Health Food Technology Co. Ltd.,Ran2023 to 2023Enrolled150ConditionsOverweight and ObesityArmsStudy product A (Wonderlab wonder4shape), Study product B (Wonderlab wonder4shape), Study product C (placebo)
NCT07483697 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Multimodal Intervention and Its Association With Reduced Dysbiosis and Inflammation in Early Chronic Kidney Disease in Young People: a Prospective Study

TypeinterventionalSponsorCentenario Hospital Miguel HidalgoRan2026 to 2026Enrolled200ConditionsExercise, Diet Interventions, Symbiotic, CKD Stage 1Armssymbiotic, Placebo
3 · Its place in the literature

Who cites it

693 citing papers in PubMed, 15 syntheses or guidelines pooled it, 1,981 citations in OpenAlex.

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  19. Effect of AG1Frontiers in nutrition · 2026
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633 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 4 countries.

Kelly S SwansonDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA. ksswanso@illinois.edu.ORCID http://orcid.org/0000-0001-5518-3076
Glenn R GibsonDepartment of Food and Nutritional Sciences, The University of Reading, Reading, UK.ORCID http://orcid.org/0000-0002-0566-0476
Robert HutkinsDepartment of Food Science and Technology, University of Nebraska - Lincoln, Lincoln, NE, USA.
Raylene A ReimerFaculty of Kinesiology and Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0001-5088-7947
Gregor ReidLawson Health Research Institute, University of Western Ontario, London, Ontario, Canada.ORCID http://orcid.org/0000-0001-9658-5696
Kristin VerbekeTranslational Research in Gastrointestinal Disorders, KU Leuven, Targid, Leuven, Belgium.ORCID http://orcid.org/0000-0002-5352-7565
Karen P ScottRowett Institute, University of Aberdeen, Aberdeen, UK.ORCID http://orcid.org/0000-0002-4608-0013
Hannah D HolscherDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0003-4918-2426
Meghan B AzadChildren's Hospital Research Institute of Manitoba, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.ORCID http://orcid.org/0000-0002-5942-4444
Nathalie M DelzenneMetabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.ORCID http://orcid.org/0000-0003-2115-6082
Mary Ellen SandersInternational Scientific Association for Probiotics and Prebiotics, Centennial, CO, USA.ORCID http://orcid.org/0000-0001-6321-3423
University of Illinois Urbana-Champaign · USChildren's Hospital Research Institute of Manitoba · CAKU Leuven · BEUCLouvain · BEUniversity of Aberdeen · GBUniversity of Calgary · CAUniversity of Nebraska–Lincoln · USUniversity of Reading · GBWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the definition and scope of synbiotics. The panel updated the definition of a synbiotic to "a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host". The panel concluded that defining synbiotics as simply a mixture of probiotics and prebiotics could suppress the innovation of synbiotics that are designed to function cooperatively. Requiring that each component must meet the evidence and dose requirements for probiotics and prebiotics individually could also present an obstacle. Rather, the panel clarified that a complementary synbiotic, which has not been designed so that its component parts function cooperatively, must be composed of a probiotic plus a prebiotic, whereas a synergistic synbiotic does not need to be so. A synergistic synbiotic is a synbiotic for which the substrate is designed to be selectively utilized by the co-administered microorganisms. This Consensus Statement further explores the levels of evidence (existing and required), safety, effects upon targets and implications for stakeholders of the synbiotic concept.

Indexed as

HumansPrebioticsProbioticsSynbioticsPrebiotics

Identifiers

PMID32826966
PMCPMC7581511
OpenAlexW2694487218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.