ArticleNature communications2020
Associations between aversive learning processes and transdiagnostic psychiatric symptoms in a general population sample.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- The global prevalence of depression, suicide ideation, and attempts in the military forces: a systematic review and Meta-analysis of cross sectional studies.BMC psychiatry · 2021Pooled it
- A core component of psychological therapy causes adaptive changes in computational learning mechanisms.Psychological medicine · 2024Trial
- Human claustrum neurons encode uncertainty and prediction errors during aversive learning.Nature neuroscience · 2026Article
- Cognitive & Behavioral Assessment Toolbox (CBAT): An open-source platform supporting experiments in computational psychiatry.Psychiatry and clinical neurosciences · 2026Article
- Negative Contextual Valence Unmasks Altered Counterfactual Decision-Making in Major Depressive Disorder.medRxiv : the preprint server for health sciences · 2026Article
- Cognitive modeling of real-world behavior for understanding mental health.Trends in cognitive sciences · 2026Review
- Transdiagnostic mental health symptom dimensions predict use of flexible model-based inference in complex environments.Translational psychiatry · 2026Article
- Cognitive arbitration between candidate dimensions of psychopathology.Molecular psychiatry · 2026Article
- OCD Compulsions as Aberrant Integration of Uncertainty from Local Goals to Global Goals.Computational psychiatry (Cambridge, Mass.) · 2026Article
- Inflammatory profiles of transdiagnostic symptom dimensions in healthy females.Brain, behavior, & immunity - health · 2025Article
- Computational signatures of uncertainty are reflected in motor cortex excitatory neurochemistry.Nature communications · 2025Article
- How working memory and reinforcement learning interact when avoiding punishment and pursuing reward concurrently.Journal of experimental psychology. General · 2025Article
- Dual process impairments in reinforcement learning and working memory systems underlie learning deficits in physiological anxiety.PLoS computational biology · 2025Article
- Article
- Reducing the burden of psychological questionnaire measures through selective item re-weighting.Royal Society open science · 2025Article
- Understanding learning through uncertainty and bias.Communications psychology · 2025Review
- Emotions and individual differences shape human foraging under threat.Nature. Mental health · 2025Article
- The Value of Non-Instrumental Information in Anxiety: Insights from a Resource-Rational Model of Planning.Computational psychiatry (Cambridge, Mass.) · 2025Article
- Signatures of Perseveration and Heuristic-Based Directed Exploration in Two-Step Sequential Decision Task Behaviour.Computational psychiatry (Cambridge, Mass.) · 2025Article
- Information search under uncertainty across transdiagnostic psychopathology and healthy ageing.Translational psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
Abstract
Symptom expression in psychiatric conditions is often linked to altered threat perception, however how computational mechanisms that support aversive learning relate to specific psychiatric symptoms remains undetermined. We answer this question using an online game-based aversive learning task together with measures of common psychiatric symptoms in 400 subjects. We show that physiological symptoms of anxiety and a transdiagnostic compulsivity-related factor are associated with enhanced safety learning, as measured using a probabilistic computational model, while trait cognitive anxiety symptoms are associated with enhanced learning from danger. We use data-driven partial least squares regression to identify two separable components across behavioural and questionnaire data: one linking enhanced safety learning and lower estimated uncertainty to physiological anxiety, compulsivity, and impulsivity; the other linking enhanced threat learning and heightened uncertainty estimation to symptoms of depression and social anxiety. Our findings implicate aversive learning processes in the expression of psychiatric symptoms that transcend diagnostic boundaries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.