ArticleNature communications2020
Adaptive self-healing electronic epineurium for chronic bidirectional neural interfaces.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 110 citations in OpenAlex.
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- Ion-shielding ultrathin encapsulation with hot-press bonded interface enables chronic stretchable bioelectronics.Science advances · 2026Article
- A conformable shape-stable self-healing polymer platform for continuous wireless arterial pulse monitoring.Nature communications · 2026Article
- Multi-Functional Adaptive Interfaces for Next-Generation Wearable and Implantable Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A Laminating Strategy to Manyfold Enhance the Elastic Stretchability of Stretchable Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- HMC3 revealed: how much do these "Microglia" really tell us?Frontiers in immunology · 2026Review
- An injectable conductive hydrogel for closed-loop and robot-assisted rehabilitation via stretchable patch-type electrodes.Nature protocols · 2026Review
- Intelligent Self-Healing Polymeric Systems for Functional and Durable Coatings.Chemistry, an Asian journal · 2026Review
- Hydrogel-elastomer-based conductive nanomembranes for soft bioelectronics.Nature nanotechnology · 2025Article
- Adhesive nonfibrotic bioelectronic interfaces on diverse peripheral nerves for long-term functional neuromodulation.Science advances · 2025Article
- Bioadhesive and conformable bioelectronic interfaces for vasomotoricity monitoring and regulation.Nature communications · 2025Article
- Performance-Recoverable Closed-Loop Neuroprosthetic System.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Neuromorphic chips for biomedical engineering.Mechanobiology in medicine · 2025Review
- Recent Advances in Stimuli-Responsive Materials and Soft Robotic Actuators for Bioelectronic Medicine.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Soft-Actuated Cuff Electrodes with Minimal Contact for Bidirectional Peripheral Interfaces.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- A Body-Temperature-Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Highly-stable, injectable, conductive hydrogel for chronic neuromodulation.Nature communications · 2024Article
- Stretchable and biodegradable self-healing conductors for multifunctional electronics.Science advances · 2024Article
- Motion artefact management for soft bioelectronics.Nature reviews bioengineering · 2024Article
- Flexible Peripheral Nerve Interfacing Electrode for Joint Position Control in Closed-Loop Neuromuscular Stimulation.Micromachines · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Realizing a clinical-grade electronic medicine for peripheral nerve disorders is challenging owing to the lack of rational material design that mimics the dynamic mechanical nature of peripheral nerves. Electronic medicine should be soft and stretchable, to feasibly allow autonomous mechanical nerve adaptation. Herein, we report a new type of neural interface platform, an adaptive self-healing electronic epineurium (A-SEE), which can form compressive stress-free and strain-insensitive electronics-nerve interfaces and enable facile biofluid-resistant self-locking owing to dynamic stress relaxation and water-proof self-bonding properties of intrinsically stretchable and self-healable insulating/conducting materials, respectively. Specifically, the A-SEE does not need to be sutured or glued when implanted, thereby significantly reducing complexity and the operation time of microneurosurgery. In addition, the autonomous mechanical adaptability of the A-SEE to peripheral nerves can significantly reduce the mechanical mismatch at electronics-nerve interfaces, which minimizes nerve compression-induced immune responses and device failure. Though a small amount of Ag leaked from the A-SEE is observed in vivo (17.03 ppm after 32 weeks of implantation), we successfully achieved a bidirectional neural signal recording and stimulation in a rat sciatic nerve model for 14 weeks. In view of our materials strategy and in vivo feasibility, the mechanically adaptive self-healing neural interface would be considered a new implantable platform for a wide range application of electronic medicine for neurological disorders in the human nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.