Evidence map›Paper›PMID 32826807›Full record

ReviewShock (Augusta, Ga.)2021

Angiogenesis: A Cellular Response to Traumatic Injury.

Anthony R Pecoraro, Brian D Hosfield, Hongge Li, William Christopher Shelley, Troy A Markel

Abstract readReview
In one paragraph

Review in Shock (Augusta, Ga.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Clinical Value and Potential Molecular Mechanism of miR-373-3p in Coronary Atherosclerosis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anthony R PecoraroDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Brian D Hosfield
Hongge Li
William Christopher Shelley
Troy A Markel
Indiana University School of Medicine

Funding

Sulfur Based Stem Cell Therapeutics in Necrotizing EnterocolitisR01DK133418 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI TROY A MARKEL · 2023 to 2026
$1.9M
Mesenchymal Stromal Cells Modulate Intestinal Mesenteric Endothelium Via Hydrogen SulfideK08DK113226 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MARKEL, TROY A · 2018 to 2021
$603k
NIDDK NIH HHS K08 DK113226NIDDK NIH HHS R01 DK133418
6 · The paper itself

Abstract

abstractThe development of new vasculature plays a significant role in a number of chronic disease states, including neoplasm growth, peripheral arterial disease, and coronary artery disease, among many others. Traumatic injury and hemorrhage, however, is an immediate, often dramatic pathophysiologic insult that can also necessitate neovascularization to promote healing. Traditional understanding of angiogenesis involved resident endothelial cells branching outward from localized niches in the periphery. Additionally, there are a small number of circulating endothelial progenitor cells that participate directly in the process of neovessel formation. The bone marrow stores a relatively small number of so-called pro-angiogenic hematopoietic progenitor cells-that is, progenitor cells of a hematopoietic potential that differentiate into key structural cells and stimulate or otherwise support local cell growth/differentiation at the site of angiogenesis. Following injury, a number of cytokines and intercellular processes are activated or modulated to promote development of new vasculature. These processes initiate and maintain a robust response to vascular insult, allowing new vessels to canalize and anastomose and provide timely oxygen delivering to healing tissue. Ultimately as we better understand the key players in the process of angiogenesis we can look to develop novel techniques to promote healing following injury.

Indexed as

Neovascularization, PhysiologicWounds and InjuriesHematopoietic Stem CellsHumansWound Healing

Identifiers

PMID32826807
PMCPMC13662874
OpenAlexW3080079315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.